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Mouse gut metagenome

ABSTRACT: Porphyromonas gingivalis impairs glucose uptake in muscle by altering gut microbiota

PROVIDER: PRJDB9383 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR212729_1.fastq.gz	Fastqsanger.gz
	DRR212729_2.fastq.gz	Fastqsanger.gz
	DRR212730_1.fastq.gz	Fastqsanger.gz
	DRR212730_2.fastq.gz	Fastqsanger.gz
	DRR212731_1.fastq.gz	Fastqsanger.gz

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Project description:Porphyromonas gingivalis impairs glucose uptake in muscle by altering gut microbiota

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Project description:Periodontitis increases the risk of non-alcoholic fatty liver disease (NAFLD). However, the precise mechanisms are unclear. Here, gut dysbiosis induced by orally administered Porphyromonas gingivalis, a representative periodontopathic bacterium, was implicated in the deterioration of NAFLD pathology. C57BL/6 mice were administered with the vehicle, P. gingivalis or Prevotella intermedia, with weaker periodontal pathogenicity, followed by feeding on a choline-deficient, high fat diet (CDAHFD60). CDAHFD60 feeding induced hepatic steatosis, and combined bacterial administration further aggravated NAFLD pathology with increased fibrosis. Liver gene expression analyses revealed that genes involved in the NAFLD pathology were perturbed with distinctive expression profiles induced by different bacteria. These differences may be due to quantitative and qualitative differences in the influx of gut bacterial products because the serum endotoxin level, gut microbiota composition, and serum metabolite profile caused by ingested P. intermedia and P. gingivalis were different. These findings provide insights into mechanisms linking periodontitis and NAFLD.

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Project description:Porphyromonas gingivalis is a gram-negative bacterium that causes destructive chronic periodontitis. In addition, this bacterium is also involved in the development of cardiovascular disease. The aim of this study was to investigate the effects of P. gingivalis infection on gene and protein expression in human aortic smooth muscle cells (AoSMCs) and its relation to cellular function.

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Project description:RNA-Seq of wild-type Porphyromonas gingivalis compared to ΔPGN_1524 mutant Illumina based RNA-Seq was used to probe transcriptome differences between wild-type Porphyromonas gingivalis and ΔPGN_1524 mutant

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Porphyromonas gingivalis gene expression during co-culture with Treponema denticola

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Project description:Porphyromonas gingivalis and Treponema denticola are periodontalpathogens that are associated with the severity and progression of periodontal diseases. this study investigates the gene expression of Treponema denticola during co-culture with Porphyromonas gingivalis.

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