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Plasmodium berghei ANKA

ABSTRACT: Whole genome resequencing of piperaquine-resistant rodent malaria parasite

PROVIDER: PRJDB9792 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	DRR228817_1.fastq.gz	Fastqsanger.gz
	DRR228817_2.fastq.gz	Fastqsanger.gz
	DRR228818_1.fastq.gz	Fastqsanger.gz
	DRR228818_2.fastq.gz	Fastqsanger.gz
	DRR228819_1.fastq.gz	Fastqsanger.gz

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Project description:Infection of C57BL/6 mice with Plasmodium berghei ANKA (PbA) is a well-established experimental model of cerebral malaria (ECM). ECM is characterised by high levels of parasite sequestration and recruitment of pathogenic CD8+ T cells to the brain. The role of CD4+ T cells in this model has not yet been fully elucidated, although our laboratory has recently shown that CD4+ T cell depletion prior to infection results in significantly lower parasite burdens and protection from ECM. These data highlight a pathogenic role for CD4+ T cells in ECM. Our unpublished observations indicate that mice lacking the CD8+ T cell cytolytic effector molecule, Granzyme B, (GzmB), are resistant to ECM, showing markedly reduced parasite burdens. Late depletion of CD4+ T cells from PbA-infected GzmB-deficient mice results in enhanced parasite burdens, indicating that these cells may play an anti-parasitic role. In the present study, we have analysed splenic CD4+ T cell gene expression profiles in naïve C57BL/6 mice, and PbA-infected wild-type and GzmB-deficent mice to further our understanding of the CD4+ T cell response in ECM.

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Splenic CD4 T cells in naïve C57BL/6 mice or during Plasmodium berghei ANKA infection in C57BL/6 and B6.GzmB-/- mice.

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Gene profiling of spleens of adult protected rats from Plasmodium berghei ANKA

Project description:The studies reported here were designed to define in more detail the effector cells responsible for the transfer of protective immunity to young host against P. berghei infection, and to investigate the genes expressed in spleen cells of adult protected rats capable of transferring protection to young rats. Keywords: age, malaria, protection, rat

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