Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lung microbiome in COPD

ABSTRACT: Characterizing the bacterial community in sequential ( stable, exacerbation and post-exacerbation) COPD sputum samples using 454GS-FLX .

PROVIDER: PRJEB12565 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	ERR1288580.fastq.gz	Fastqsanger.gz
	ERR1288600.fastq.gz	Fastqsanger.gz
	ERR1288610.fastq.gz	Fastqsanger.gz
	ERR1288620.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 85

Similar Datasets

Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD

Project description:Long-term, low dose azithromycin reduces exacerbation frequency in COPD yet the mechanism remains unclear. This study characterises changes to gene expression in patients with neutrophilic COPD in response to long term low dose azithromycin therapy. Patients with neutrophilic COPD (>61% or >162x10^4/mL sputum neutrophils) were randomised to 12 weeks of either azithromycin or placebo treatment. RNA was extracted from sputum and blood collected before (pre) and after (post) treatment.

2018-11-14 | GSE119314 | GEO

Vastus lateralis muscle of patients with an acute COPD exacerbation

Project description:To further unravel the potential molecular mechanisms involved in the loss of muscle function during an acute exacerbation, a cross-sectional microarray study was designed to compare the gene expression profile of the vastus lateralis muscle in patients with an acute COPD exacerbation and in stable COPD patients. Keywords: cross-sectional patient study A cross-sectional microarray study was designed. The microarray screening was performed on a vastus lateralis biopsy obtained from 4 patients with an acute COPD exacerbation and 5 stable COPD patients. No replicates or dye-swaps were included.

2009-03-13 | E-GEOD-10828 | biostudies-arrayexpress

Association of sputum microbiome with exacerbations, patient subgroups and host response in chronic obstructive pulmonary disease

Project description:Little is known about the lung microbiome dynamics and host-microbiome interactions in relation to chronic obstructive pulmonary disease (COPD) exacerbations and in patient subgroups based on smoking status and disease severity. Here we performed a 16S ribosomal RNA survey on sputum microbiome from 16 healthy and 43 COPD subjects. For COPD subjects, a longitudinal sampling was performed from stable state to exacerbations, at two and six weeks post-exacerbations and at six months from first stable visit. Host sputum transcriptome were characterized for a subset of COPD patient samples.

2021-03-21 | GSE112165 | GEO

Vastus lateralis muscle of patients with an acute COPD exacerbation

2009-03-14 | GSE10828 | GEO

Samples from exacerbating COPD subjects before and after treatment with nemiralisib

Project description:To study the effects of treatment with an inhaled PI3Kδ inhibitor during recovery from an exacerbation of Chronic Obstructive Pulmonary Disease (COPD) due to corrective effects on neutrophils that display dysregulated migration characteristics. We aimed to develop novel induced sputum endpoints to demonstrate changes in neutrophil phenotype and proof of mechanism of action in the lung.

2020-12-31 | GSE148871 | GEO

Samples from stable COPD subjects before and after treatment with nemiralisib

2020-12-31 | GSE148877 | GEO

COPD Microbiome study

Project description:Microbiome in acute exacerbation and stable phase of COPD: a descriptive and comparative study of 16s rRNA sequencing and metagenomic sequencing

| PRJEB40507 | ENA

COPD Lung Microbiome

Project description:Metagenomic analysis of the induced sputum samples from non-smoker COPD, smoker-COPD, and healthy rural Indian subjects

| PRJEB20464 | ENA

Analysis of sputum methylation data in Asthma and COPD

Project description:We evaluated the applicability and usability of whole-genome methylomics of sputum samples in molecular profiling of chronic inflammatory lung diseases. Genomic DNA was purified from sputum samples of subjects with Asthma, COPD as well as healthy controls and analyzed on the Illumina Infinium HumanMethylation 450k platform.

2020-10-25 | GSE148000 | GEO

Severity of lung function impairment drives transcriptional phenotypes of COPD and relates to immune and metabolic processes

Project description:Gene expression profiles were generated from induced sputum samples in COPD and healthy controls. The study identified transcriptional phenotypes of COPD.

2023-08-31 | GSE212331 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data