Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

M. aurum full genome

ABSTRACT: Mycobacterium aurum as a surrogate for drug screening

PROVIDER: PRJEB13254 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	GCA_900078775.1_sequence_report.txt	Txt

Items per page:

1 - 1 of 1

Similar Datasets

Aurum Assembly

Project description:Genome assembly of Mycobacterium aurum.

| PRJEB8229 | ENA

Mycolicibacterium aurum

Project description:Mycolicibacterium aurum overview

| PRJNA844436 | ENA

Microbacterium aurum

Project description:Microbacterium aurum overview

| PRJNA358117 | ENA

Microbacterium aurum strain:KACC15219

Project description:Microbacterium aurum strain:KACC15219 Genome sequencing and assembly

| PRJNA353137 | ENA

Microbacterium aurum strain:DSM 8600 | isolate:DSM 8600

Project description:Microbacterium aurum DSM 8600 genome sequencing

| PRJNA695676 | ENA

Microbacterium aurum strain:IFO 15204

Project description:Whole Genome sequencing and assembly of Microbacterium aurum IFO 15204T

| PRJNA357927 | ENA

Mycolicibacterium aurum strain:NCT 10437 | isolate:tree

Project description:Mycolicibacterium aurum strain:NCT 10437 | isolate:tree Genome sequencing

| PRJNA543719 | ENA

Project description:Whole genome sequences of mycobacterium aurum

| PRJNA598519 | ENA

The human pathogen Mycobacterium tuberculosis and the fish pathogen Mycobacterium marinum trigger the same core set of late immune response genes in zebrafish larvae

Project description:Zebrafish is a natural host of various Mycobacterium species and a surrogate model organism for tuberculosis research. Mycobacterium marinum (M. marinum) is evolutionarily most closely related to M. tuberculosis and shares the majority of virulence genes. Although zebrafish is not a natural host of the human pathogen, we have previously demonstrated successful robotic infection of zebrafish embryos with M. tuberculosis and performed drug treatment of the infected larvae. In the present study we examined for how long M. tuberculosis can be propagated in zebrafish larvae and tested a time series of infected larvae to study the transcriptional response via Illumina RNAseq. Granuloma-like structures carrying fluorescently labeled M. tuberculosis could be detected up to 9 days post infection. The continued presence of viable M. tuberculosis in the zebrafish larvae was further confirmed using the molecular bacterial load assay. The infected larvae showed a clear and specific transcriptional immune response with a high similarity to the response of zebrafish larvae infected with the surrogate species M. marinum. We conclude that M. tuberculosis can be propagated in zebrafish larvae for at least one week after infection and provide further evidence that M. marinum is a good surrogate model for M. tuberculosis.

2024-01-08 | GSE252417 | GEO

Homo sapiens

Project description:Transcriptome of THP1 macrophage infected with Mycobacterium aurum

| PRJNA575195 | ENA