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Metagenomic analysis of gut microbiota in sows

ABSTRACT: We studied the effect of different zinc sources on the intestinal microbiome in weaned pigs

PROVIDER: PRJEB21574 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR2020020_1.fastq.gz	Fastqsanger.gz
	ERR2020020_2.fastq.gz	Fastqsanger.gz
	ERR2020030_1.fastq.gz	Fastqsanger.gz
	ERR2020030_2.fastq.gz	Fastqsanger.gz
	ERR2020021_1.fastq.gz	Fastqsanger.gz

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Evaluation of intestinal response to zinc restriction and zinc sources in pigs

Project description:We evaluated the intestinal responses of pigs under zinc restriction and under different zinc sources through RNA-seq of ileal samples. We identified changes in genes related to zinc transport, immune response, cell proliferation, DNA damage and stress resposne. Our findings demonstrate that swine intestine is responsive to zinc restriction and can be a model sentinel tissue for human zinc deficiency. Further research is needed to define the intestinal responses to organic and inorganic zinc sources.

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Project description:EMG produced TPA metagenomics assembly of PRJEB21574 data set (We studied the effect of different zinc sources on the intestinal microbiome in weaned pigs).

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Evaluation of intestinal response to zinc restriction and zinc sources in pigs

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Project description:An early settlement of a complex gut microbiota can protect against gastro-intestinal dysbiosis, but the effects of neonatal microbiota colonization on the maturation of the porcine gastric mucosa are largely unknown. The transcriptome of the oxyntic mucosa of 12 caesarian-derived pigs previously associated with microbiota of different complexity was studied. Pigs received sow blood serum at birth (d0), 2 mL of starter microbiota (10^7 CFU of each Lactob. Amylovorus (LAM), Clostr. glycolicum, and Parabacteroides spp.) on d1-d3 of age and either a placebo inoculant (simple association, SA) or an inoculant consisting of diluted feces of an adult sow (complex association, CA) on d3-d4 of age. Then pigs were fed a moist diet . Gastric samples were obtained at on euthanised pigs at 2 weeks of age.

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Multi-omic biogeography of the gastrointestinal microbiota of a pre-weaned lamb

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