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Mucor outbreak in a burn unit

ABSTRACT: Outbreak of invasive wound mucormycosis due to multiple strains of Mucor circinelloides f. circinelloides resolved by whole genome sequencing

PROVIDER: PRJEB23686 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR2211740_1.fastq.gz	Fastqsanger.gz
	ERR2211740_2.fastq.gz	Fastqsanger.gz
	ERR2211750_1.fastq.gz	Fastqsanger.gz
	ERR2211750_2.fastq.gz	Fastqsanger.gz
	ERR2211760_1.fastq.gz	Fastqsanger.gz

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Host-pathogen transcriptomics of Mucor circinelloides spores phagocytosed by mouse macrophages

Project description:Here, we have studied the first stage of this infection—the interaction of Mucor circinelloides spores with phagocytic cells—from an integrated transcriptomic and functional perspective. Our transcriptomic results showed that a relevant gene network is remodelled in response to phagocytosis, enriched in crucial functions to survive the phagosome, such as nutritional adaptation and response to oxidative stress. An additional transcriptomic analysis of atf1 and atf2 mutants unveiled the complex gene network of secondarily regulated genes involved in the response to phagocytosis. These new insights into the initial phase of mucormycosis define genetic regulators and molecular processes that could serve as pharmacological targets.

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Project description:Mucor species belongs to the Mucorales order within the phylum Mucoromycota, an early diverging fungal lineage. The purpose of this study was to investigate at the transcriptome scale the similarities and differences that could be linked to different lifestyles. Five strains pertaining to five species were studied: M. fuscus and M. lanceolatus, two species used in cheese ripening, M. racemosus, a recurrent cheese spoiler sometimes described as an opportunistic pathogen, M. circinelloides, often described as an opportunistic pathogen and M. endophyticus, a plant endophyte species.

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