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Bacteriophage specific to sex pilus in bacteria combat antibiotic resistance.

ABSTRACT: Sex pilus specific bacteriophage to drive bacterial population towards antibiotic sensitivity.

PROVIDER: PRJEB26354 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR2531853_1.fastq.gz	Fastqsanger.gz
	ERR2531853_2.fastq.gz	Fastqsanger.gz
	ERR2531854_1.fastq.gz	Fastqsanger.gz
	ERR2531854_2.fastq.gz	Fastqsanger.gz

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Sex pilus specific bacteriophage to drive bacterial population towards antibiotic sensitivity.

Project description:Antimicrobial resistance (AMR) is now a major global problem largely resulting from the overuse of antibiotics in humans and livestock. In some AMR bacteria, resistance is encoded by conjugative plasmids expressing sex-pili that can readily spread resistance through bacterial populations. The aim of this study was to use sex pilus-specific (SPS) phage to reduce the carriage of AMR plasmids. Here, we demonstrate that SPS phage can kill AMR Escherichia coli and select for AMR plasmid loss in vitro. For the first time, we also demonstrate that SPS phage can both prevent the spread of AMR Salmonella Enteritidis infection in chickens and shift the bacterial population towards antibiotic sensitivity.

| S-EPMC6717204 | biostudies-literature

Flagellar mutants have reduced pilus synthesis in Caulobacter crescentus

Project description:Surface appendages such as flagella and type IV pili mediate a broad range of bacterial behaviors including motility, attachment, and surface sensing. While many species harbor both flagella and type IV pili, little is known about how or if their synthesis is coupled. Here, we show that deletions of genes encoding different flagellum machinery components result in a reduction of pilus synthesis in Caulobacter crescentus. First, we show that different flagellar mutants exhibit different levels of sensitivity to a pilus-dependent phage and that less cells within populations of flagellar mutants make pili. Furthermore, we find that single cells within flagellar mutant populations produce less pili per cell. We demonstrate that these gene deletions result in reduced transcription of pilus-associated genes and have a broad effect on global transcription profiles. Finally, we show that the decrease in pilus production is due to a reduction in the pool of pilin subunits that are polymerized into pilus fibers. These data demonstrate that mutations in flagella gene components affect not only motility but can also have considerable and unexpected consequences on other aspects of cell biology.

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Transcriptome analysis of wt Pilus-1 expressing Streptococcus pneumoniae strains

Project description:The Streptococcus pneumoniae Pilus-1 Displays a Biphasic Expression Pattern

2011-07-01 | E-TABM-1154 | biostudies-arrayexpress

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