Project description:Renibacterium salmoninarum is a Gram-positive, intracellular bacterial pathogen that causes Bacterial Kidney Disease (BKD) in Atlantic salmon (Salmo salar). To identify R. salmoninarum bacterin-responsive genes in Atlantic salmon, fish (n=6) were intraperitoneally injected with a high (5×107 cells/kg; High-Rs) dose of formalin-killed R. salmoninarum or phosphate-buffered saline (PBS control). Head kidney samples were collected at 24 h post-injection. Using 44K microarray analysis, transcriptome analysis was performed to identify differentially expressed probes in response to formalin-killed R. salmoninarum injection.

2020-07-21 | GSE135168 | GEO

Comparative proteome analysis of the dish pathogen Renibacterium salmoninarum grown under rich- and iron‐limited conditions

Project description:Proteomic analysis of iron restriction of the marine pathogen Renibacterium salmoninarum that causes the disease (BKD), in this study two isolated Chilean H-2 strains and the type strain ATCC33209 have been used. These results show that changes are generated at the level of protein expression in pathways involved in iron metabolism and uptake.

2021-11-29 | PXD024459 | Pride

Transcriptomic profiling of the adaptive and innate immune responses of Atlantic salmon to Renibacterium salmoninarum infection

Project description:Renibacterium salmoninarum is a Gram-positive, intracellular bacterial pathogen that causes Bacterial Kidney Disease (BKD) in Atlantic salmon (Salmo salar). To identify Atlantic salmon genes responsive to R. salmoninarum pathogen, fish were intraperitoneally injected with R. salmoninarum (BKD) or sterile KDM-2 medium (control). Head kidney samples were collected at 13 days post-infection. Using 44K microarray analysis, transcriptome analysis was performed to identify differentially expressed probes in response to different levels of R. salmoninarum infection.

2020-09-24 | GSE150335 | GEO

Renibacterium salmoninarum strain:H2

Project description:Renibacterium salmoninarum strain:H2 Genome sequencing

| PRJNA379973 | ENA

Renibacterium salmoninarum strain:DJ2R

Project description:Renibacterium salmoninarum strain:DJ2R Genome sequencing

| PRJNA379977 | ENA

Genomic epidemiology of the commercially important pathogen Renibacterium salmoninarum within the Chilean salmon industry.

Project description:Renibacterium salmoninarum is the causative agent of bacterial kidney disease (BKD), which is a commercially important disease of farmed salmonids. Typing by conventional methods provides limited information on the evolution and spread of this pathogen, as there is a low level of standing variation within the R. salmoninarum population. Here, we apply whole-genome sequencing to 42 R. salmoninarum isolates from Chile, primarily from salmon farms, in order to understand the epidemiology of BKD in this country. The patterns of genomic variation are consistent with multiple introductions to Chile, followed by rapid dissemination over a 30 year period. The estimated dates of introduction broadly coincide with major events in the development of the Chilean aquaculture industry. We find evidence for significant barriers to transmission of BKD in the Chilean salmon production chain that may also be explained by previously undescribed signals of host tropism in R. salmoninarum. Understanding the genomic epidemiology of BKD can inform disease intervention and improve sustainability of the economically important salmon industry. This article contains data hosted by Microreact.

| S-EPMC6202448 | biostudies-literature

Profiling the transcriptome response of Atlantic salmon to formalin-killed Renibacterium salmoninarum

Project description:Profiling the transcriptome response of Atlantic salmon to formalin-killed Renibacterium salmoninarum

| PRJNA557654 | ENA