Genomics

Dataset Information

0

A neoepitope derived from a novel human germline APC gene mutation in Familial Adenomatous Polyposis shows selective immunogenicity


ABSTRACT: In this study we have identified a family affected with FAP from rural India in which 10 out of the 26 members carry a novel germline mutation in the APC gene. Of these, six have been diagnosed with polyps and four remain polyp free. From a novel therapeutic standpoint, we sought to determine if peptides derived from the novel APC gene mutation could induce a cytotoxic T cell response, thereby qualifying them as cancer vaccine candidates. Only one (of 5) mutant peptide derived from the novel APC gene mutation was found to be selectively immunogenic. Additionally, experimental testing of six previously reported APC gene mutation-derived peptides revealed one of the six to be immunogenic. We concluded that while not all APC mutant peptides are immunogenic, a library of empirically confirmed ones could qualify as vaccine candidates designed to target somatic mutations in the APC gene that drive the formation of colon polyps.

PROVIDER: PRJEB27848 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
ERR2714261_1.fastq.gz Fastqsanger.gz
ERR2714261_2.fastq.gz Fastqsanger.gz
ERR2714262_1.fastq.gz Fastqsanger.gz
ERR2714262_2.fastq.gz Fastqsanger.gz
ERR2714263_1.fastq.gz Fastqsanger.gz
Items per page:
1 - 5 of 6

Similar Datasets

2020-11-01 | E-MTAB-9187 | biostudies-arrayexpress
2016-08-01 | GSE73547 | GEO
2024-06-16 | PXD043022 | Pride
2021-09-22 | GSE180160 | GEO
2011-10-26 | E-GEOD-33295 | biostudies-arrayexpress
2015-01-31 | E-GEOD-65461 | biostudies-arrayexpress
2019-10-25 | GSE109308 | GEO
2008-04-01 | E-GEOD-9689 | biostudies-arrayexpress
2008-04-01 | GSE9689 | GEO
2005-12-25 | GSE3898 | GEO