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TNBS mice metagenomics

ABSTRACT: TNBS mice metagenomics

PROVIDER: PRJEB28161 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	MGG03232.fasta.gz	Fasta.gz
	MGG03224.fasta.gz	Fasta.gz
	MGG03231.fasta.gz	Fasta.gz
	MGG03227.fasta.gz	Fasta.gz

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Colonic tissues from an acute TNBS-induced colitis model in SJL mice.

Project description:Experimental colitis is often used as a model for the inflammatory bowel diseases, ulcerative colitis and Crohn’s disease. Results identify the inflammatory processes during acute colitis in affected tissues from TNBS-treated susceptible 5-7 week old SJL mice. Keywords: Disease state analysis

2008-09-08 | GSE12139 | GEO

Transcription profiling of nouse TNBS-induced murine colitis

Project description:We investigated the relationship between chronic inflammation and fibrosis in a mouse model of chronic colitis. Six weekly Trinitrobenzenesulphonic acid (TNBS) enemas were given to establish colitis and temporal changes in gene expression was elucidated over the next six weeks. Experiment Overall Design: After the six TNBS enemas, mice were sacrificed at 3 days (termed as TNBS-w6, n=6), 2 weeks (TNBS-w8, n=4), 4 weeks (TNBS-w10, n=5), or 6 weeks (TNBS-w12, n=4). The saline control groups were also sacrificed at week 6 (Saline-w6, n=5), week 8 (n=2) and week 10 (n=2). The last two sets were pooled as Saline-w10 (n=4). Two replicates of saline-w6 were analyzed. We compared Saline-w6 with TNBS-w6, and Saline-w10 with TNBS-w8, TNBS-w10, TNBS-w12, respectively.

2008-06-14 | E-GEOD-5864 | biostudies-arrayexpress

Evaluation of coloncyte genes in TNBS-induced colitis mice treated with I3C

Project description:Transcriptome analysis was performed on enriched colon-dervied epithelial cells from non-colitis and TNBS-induced female Balb/cJ mice untreated or treated with indole-3-carbinol (I3C). We used microarrays to detail the global programme of gene expression to identify distinct classes of upregulated and downregulated genes among experimental groups.

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Project description:Background: MicroRNAs (miRNAs) acting as negative regulators of gene expression are differentially expressed in intestinal tissues of patients with inflammatory bowel disease (IBD). Assessing the functional role of miRNAs in murine models of colitis facilitates elucidating the role of specific miRNAs in human IBD. The aim of this study was to determine the miRNA signature of murine models of colitis and to assess the influence of miR-21 on intestinal inflammation. Methods: miRNAs expression was accessed by microarray for acute and chronic murine model of colitis induced by DSS or TNBS. miR-21-deficient mouse and littermates controls were assessed in the standard DSS, TNBS and CD4+ T cell transfer models of colitis. RNAs of mouse colon and CD4+CD45RBHigh cells were analyzed by miRNA and mRNA microarray, and quantitative RT-PCR. Th1 polarization was accessed by flow-cytometry and ELISA. Results: Alterations of in miRNAs expression were identified for acute and chronic DSS colitis and TNBS colitis, receptively. The Expression of miRs-21, -142-3p and -223 was were distinct between DSS and TNBS models while overlap of numerous miRNAs was seen. Importantly, miRs-19b, -192 and -215, that are decreased in IBD, were significantly decreased in all 4 models of colitis. miR-21, which is increased in IBD, was increased in TNBS colitis but not the DSS colitis models. Further assessment of the miR-21-deficient 1-/- mice revealed that the deletion of miR-21 results in the exacerbation of both the TNBS and T cell-transfer models of colitis. Conclusions: miRNAs are differentially expressed in both human IBD and murine colitis, with overlap of several IBD-associated miRNAs. The demonstration that miR-21 deletion exacerbated CD4+ T cell-mediated models of colitis provides further evidence that miRNAs play significant roles in the pathogenesis of IBD.

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Chronic TNBS Colitis in the FN14 KO Mouse

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eATP-responsive synthetic yeast ameliorate TNBS-induced colitis

Project description:By combining directed evolution and synthetic biology, we engineered novel synthetic yeasts probiotics for the dynamic modulation of intestinal inflammation. In this experiment we treated TNBS-colitis induced mice with these probiotics and test the amelioration of immune response in the transcriptional level in the colon.

2021-04-22 | GSE152869 | GEO

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Project description:Rats were randomly assigned to one of two different groups, a control (C, n=6) group that received a saline enema and a TNBS group (n=6) that received the TNBS challenge. Colonic epithelial cells were isolated from the distal colon of control and TNBS (non necrosed) rats by calcium chelation and percoll purification. Two mRNA samples were obtained from isolated control and TNBS rat colonocytes (pooled from n=6) further characterized with microarrays.

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Chronic TNBS Colitis in the FN14 KO Mouse

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Project description:To obtain insight into the complex traits underlying the local pathophysiological response to the repeated colitis inductions with TNBS, whole genome gene expression was performed on RNA isolated from the distal colon tissue of 5 mice/timepoint Total RNA obtained from isolated from the distal colon of TNBS colitis mice (isolated on day 9, 14, 16, 21, 23, and 28) was compared to those healthy control mice

2013-07-08 | E-GEOD-35609 | biostudies-arrayexpress

Analysis of temporal gene expression responses during TNBS-induced colitis development

2013-07-08 | GSE35609 | GEO