Fungal microbiota dysbiosis in IBD
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB30383 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ERR3003100.fastq.gz | Fastqsanger.gz | |||
| ERR3003110.fastq.gz | Fastqsanger.gz | |||
| ERR3003120.fastq.gz | Fastqsanger.gz | |||
| ERR3003130.fastq.gz | Fastqsanger.gz | |||
| ERR3003140.fastq.gz | Fastqsanger.gz |
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Project description:Fungal microbiota dysbiosis in IBD PMID: 26843508 RUN3
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Project description:The goal of this project is to find out whether human intestinal IgA1 and IgA2 secretion, transport and reactivity towards the microbiota might be involved in dysbiosis induction during Crohn’s disease and Ulcerative colitis. Mass spectrometry was used to characterize SIgA from Crohn’s disease patient and Ulcerative colitis patient, in term of O- and N-glycosylation in order to study their reverse transcytosis capacity and their role in intestinal inflammation.
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Project description:Tryptophan metabolism and bacterial commensals prevent fungal dysbiosis in Arabidopsis roots, Fungal data
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Project description:Gut microbiota and their metabolites influence host gene expression and physiological status through diverse mechanisms. Here we investigate how gut microbiota and their metabolites impact host′s mRNA m6A epitranscriptome in various antibiotic-induced microbiota dysbiosis models. With multi-omics analysis, we find that the imbalance of gut microbiota can rewire host mRNA m6A epitranscriptomic profiles in brain, liver and intestine. We further explore the underlying mechanisms regulating host mRNA m6A methylome by depleting the microbiota with ampicillin. Metabolomic profiling shows that cholic acids are the main down-regulated metabolites with Firmicutes as the most significantly reduced genus in ampicillin-treated mice comparing to untreated mice. Fecal microbiota transplantations in germ-free mice and metabolites supplementations in cells verify that cholic acids are associated with host mRNA m6A epitranscriptomic rewiring. Collectively, this study employs an integrative multi-omics analysis to demonstrate the impact of gut microbiota dysbiosis on host mRNA m6A epitranscriptomic landscape via cholic acid metabolism.
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Project description:Tryptophan metabolism and bacterial commensals prevent fungal dysbiosis in Arabidopsis roots, Bacterial data
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Project description:Tryptophan metabolism and bacterial commensals prevent fungal dysbiosis in Arabidopsis roots, Oomycetal data
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