Project description:In this study, the protective effect of melatonin and m6A on mouse pregnancy was studied by constructing an LPS-induced abnormal early pregnancy model in mice. Pregnant ICR mice were selected and intraperitoneal injection of LPS on D3 and D4 of pregnancy, melatonin was found to alleviated LPS-induced reductions in the number of implantation sites. Besides, melatonin alleviated the activation of inflammation, autophagy and apoptosis pathways, thereby protecting the pregnancy process of mice. We monitored m6A methylation by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and m6A-sequencing (m6A-seq), we found that melatonin regulated m6A methylation levels.

2024-01-31 | GSE216994 | GEO

SARS-CoV-2 infection elucidates unique features of pregnancy-specific immunity [VDJ]

Project description:Pregnancy is a risk factor for increased severity of SARS-CoV-2 and other respiratory infections. The mechanisms underlying this risk have not been well-established, partly due to limited understanding of how pregnancy shapes and modulates immune responses. To gain insight into the roles of pregnancy in shaping the immune responses we collected peripheral blood mononuclear cells (PBMC) from 17 non-pregnant and 9 pregnant donors with various COVID severities and compared their immunological profiles.

2024-10-30 | GSE239451 | GEO

SARS-CoV-2 infection elucidates unique features of pregnancy-specific immunity [GEX]

2024-10-30 | GSE239450 | GEO

SARS-CoV-2 infection elucidates unique features of pregnancy-specific immunity [ADT]

2024-10-30 | GSE239449 | GEO

Metabarcoding Analysis of Oral Microbiome during pregnancy

Project description:Metabarcoding Analysis of Oral Microbiome during pregnancy

| PRJEB82957 | ENA

Mapping quantitative trait loci and developing their KASP markers for Pre-harvest Sprouting resistance of Henan wheat varieties in China

Project description:Mapping quantitative trait loci and developing their KASP markers for Pre-harvest Sprouting resistance of Henan wheat varieties in China

| PRJNA919175 | ENA

Study the genetic susceptibility of esophagus squamous cell carcinomas (ESCC) in high-risk area Henan Chinese

Project description:This study utilized a genetically-enriched cohort of patients with familial ESCC from the high-risk Henan region, located near the Tai-Hang Mountain region in Northern China, to identify high penetrance ESCC predisposition genes using a comprehensive unbiased whole-exome sequencing (WES) strategy. Subsequent validate the prevalence of rare damage variants by targeted gene sequencing in a large sample size.

| EGAS00001003423 | EGA

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