Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect on Plasmodium falciparum of a 4-cyano-3-methylisoquinoline inhibitor

ABSTRACT: Mechanisms of inhibition of Plasmodium falciparum growth by a novel 4-cyano-3-methylisoquinoline compound

PROVIDER: PRJEB31982 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR3262030_1.fastq.gz	Fastqsanger.gz
	ERR3262030_2.fastq.gz	Fastqsanger.gz
	ERR3262040_1.fastq.gz	Fastqsanger.gz
	ERR3262040_2.fastq.gz	Fastqsanger.gz
	ERR3262050.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 95

Similar Datasets

Effect of choline kinase inhibitor hexadecyltrimethylammonium bromide on Plasmodium falciparum gene expression

Project description:Investigations on the fundamental of malaria parasite biology, such as invasion, growth cycle, metabolism and cell signalling have uncovered a number of potential antimalarial drug targets, including choline kinase, a key enzyme involved in the synthesis of phosphatidylcholine, an important component in parasite membrane compartment. The effect on gene expression of Plasmodium falciparum K1 strain following 72 hours exposure to 2 M-NM-<M (IC50 concentration) of the choline kinase inhibitor, hexadecyltrimethylammonium bromide (HDTAB) was evaluated by DNA microarray analysis. Genes important in P. falciparum intra-erythrocytic life cycle, such as invasion, cytoadherance and growth were among those affected by at least 2-fold changes in their expression levels compared with non HDTAB-treated control. Two different cultures of P. falciparum was divided into two groups, untreated and HDTAB treated. The parasites were incubated for 72 hours and harvested for total RNA extraction. The expression profile was analysed by microarray.

2014-02-08 | E-GEOD-54775 | biostudies-arrayexpress

Effect of choline kinase inhibitor hexadecyltrimethylammonium bromide on Plasmodium falciparum gene expression

Project description:Investigations on the fundamental of malaria parasite biology, such as invasion, growth cycle, metabolism and cell signalling have uncovered a number of potential antimalarial drug targets, including choline kinase, a key enzyme involved in the synthesis of phosphatidylcholine, an important component in parasite membrane compartment. The effect on gene expression of Plasmodium falciparum K1 strain following 72 hours exposure to 2 μM (IC50 concentration) of the choline kinase inhibitor, hexadecyltrimethylammonium bromide (HDTAB) was evaluated by DNA microarray analysis. Genes important in P. falciparum intra-erythrocytic life cycle, such as invasion, cytoadherance and growth were among those affected by at least 2-fold changes in their expression levels compared with non HDTAB-treated control.

2014-02-08 | GSE54775 | GEO

Identification of antimalarial compounds that inhibit Apicomplexan AP2 transcription factor proteins in the human malaria parasite Plasmodium falciparum

Project description:Transcription time course of Plasmodium falciparum parasite asexual blood stage progression in the presence of antimalarial drug CID5750730 (Compound C)

2022-05-13 | GSE202876 | GEO

Plasmodium falciparum NF54 Transcriptome

Project description:Transcriptomic Analysis of Cultured Sporozoites of P. falciparum RNA-seq reads from each of three developmental stages (2 replicates per sample) were mapped to the reference Plasmodium falciparum genome, and gene expression levels were calculated for each sample.

2013-12-03 | E-GEOD-52867 | biostudies-arrayexpress

Plasmodium falciparum

Project description:Plasmodium falciparum Epigenomics

| PRJNA349753 | ENA

A comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation

Project description:Epigenetic mechanisms have been poorly understood in Plasmodium falciparum, the causative agent of malaria. To elucidate stage specific epigenetic regulations in P. falciparum, we performed genome-wide mapping of various histone modifications, nucleosomes and RNA Polymerase II. Our comprehensive analysis suggest that transcription initiation and elongation are distinct in Plasmodium. In this study, by analyzing histone modifications, nucleosome occupancy and RNA Polymerase II (Pol II) at three different IEC developmental stages of Plasmodium; ring, trophozoite and schizont, we tried to unravel the epigenetic mechanism associated with gene regulation. Examination of H3K27me3, H3K4me3, H3K9me3, H3K14ac, H3K4me1, H3K79me3, H3K27ac, H3K4me2, H3K9ac, H4ac, RNA Pol II and Histone H3 at three different stages of Plasmodium falciparum

2015-09-23 | E-GEOD-63369 | biostudies-arrayexpress

Plasmodium falciparum

Project description:Functional genomics investigation of PfAdoMetDC/ODC co-inhibition of Plasmodium falciparum

| PRJNA110681 | ENA

Small molecule transcriptional responses in Plasmodium falciparum

Project description:Comparison of whole genome gene expression profiles for Plasmodium falciparum parasites perturbed with small molecules with diverse mechanisms of action. Perturbations were performed by treating each synchronized parasite culture with a given small molecule at 24 hrs post-eryhrocyte invasion and RNA collected 2 hrs post-exposure

2015-12-01 | GSE67127 | GEO

Plasmodium falciparum

Project description:Plasmodium falciparum malaria studies

| PRJNA447987 | ENA

Plasmodium falciparum

Project description:Hesparadin-resistant Plasmodium falciparum

| PRJNA597922 | ENA