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Experimental evidence for adaptation to species-specific gut microbiota in house mice

ABSTRACT: Experimental evidence for adaptation to species-specific gut microbiota in house mice

PROVIDER: PRJEB33256 | ENA |

REPOSITORIES: ENA

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Experimental Evidence for Adaptation to Species-Specific Gut Microbiota in House Mice.

Project description:The gut microbial communities of mammals have codiversified with host species, and changes in the gut microbiota can have profound effects on host fitness. Therefore, the gut microbiota may drive adaptation in mammalian species, but this possibility is underexplored. Here, we show that the gut microbiota has codiversified with mice in the genus Mus over the past ∼6 million years, and we present experimental evidence that the gut microbiota has driven adaptive evolution of the house mouse, Mus musculusdomesticus Phylogenetic analyses of metagenome-assembled bacterial genomic sequences revealed that gut bacterial lineages have been retained within and diversified alongside Mus species over evolutionary time. Transplantation of gut microbiotas from various Mus species into germfree M. m. domesticus showed that foreign gut microbiotas slowed growth rate and upregulated macrophage inflammatory protein in hosts. These results suggest adaptation by M. m. domesticus to its gut microbiota since it diverged from other Mus species.IMPORTANCE The communities of bacteria that reside within mammalian guts are deeply integrated with their hosts, but the impact of this gut microbiota on mammalian evolution remains poorly understood. Experimental transplantation of the gut microbiota between mouse species revealed that foreign gut microbiotas lowered the host growth rate and upregulated the expression of an immunomodulating cytokine. In addition, foreign gut microbiotas increased host liver sizes and attenuated sex-specific differences in host muscle and fat content. These results suggest that the house mouse has adapted to its species-specific gut microbiota.

| S-EPMC6620377 | biostudies-literature

Experimental evidence that root-associated fungi improve plant growth at high altitude

Project description:Experimental evidence that root-associated fungi improve plant growth at high altitude

| PRJEB65743 | ENA

Experimental tests strongly challenge the evidence of a healthy human blood microbiome

Project description:Experimental tests strongly challenge the evidence of a healthy human blood microbiome

| PRJNA1072063 | ENA

Gut microbiota in house mouse hybrid zone

Project description:Gut microbiota in house mouse hybrid zone

| PRJEB64771 | ENA

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Project description:house mouse Genome sequencing and assembly

| PRJNA884090 | ENA

Expression data from lungs of Vldlr-/- mice and wild type (WT) B6129SF2/J mice that had received intranasal house dust mite (HDM) challenges to induce experimental asthma or saline, as a control.

Project description:The very low density lipoprotein receptor (VLDLR) is a multi-ligand receptor that mediates pleiotropic biological processes, such as brain development. In this dataset, we include the expression data obtained from lungs from mice that had been challenged with house dust mite to induce experimental asthma or saline, as a control. These data are used to obtain genes that are differentially expressed in response to VLDLR signaling.

2014-03-28 | GSE55247 | GEO

Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia

Project description:Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia

| PRJNA968000 | ENA

Gastrointestinal microbiota of wild and inbred house mouse

Project description:Gastrointestinal microbiota of wild and inbred house mouse

| PRJEB6634 | ENA

Social transfer of gut microbiota in house mouse

Project description:Social transfer of gut microbiota in house mouse

| PRJEB72825 | ENA

Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations

Project description:Divergent adaptation can be associated with reproductive isolation in the process of speciation. We recently demonstrated the link between divergent adaptation and the onset of reproductive isolation in experimental populations of the yeast Saccharomyces cerevisiae evolved from a single progenitor in either a high-salt or a low-glucose environment. However, the genetic basis for adaptation and reproductive isolation remained unknown in this system. Here, we use whole-genome re-sequencing of representatives of three populations to identify 15 candidate mutations, six of which explained the adaptive increases in mitotic fitness in the two environments. In two populations evolved in high salt, two different mutations occurred in the proton efflux pump gene PMA1 and the global transcriptional repressor gene CYC8; the ENA genes encoding sodium efflux pumps were over-expressed once through expansion of this gene cluster and once as a result of the mutation in the regulator CYC8. In the population from low glucose, one mutation occurred in MDS3, which modulates growth at high pH, and one in MKT1, a global regulator of mRNAs encoding mitochondrial proteins, the latter recapitulating a naturally-occurring variant. A Dobzhansky-Muller (DM) incompatibility between the evolved alleles of PMA1 and MKT1 strongly depressed fitness in the low-glucose environment. This DM interaction is the first reported between experimentally evolved alleles of known genes and shows how reproductive isolation can arise rapidly when divergent selection is strong. Evolved and progenitor strains were grown in stressed and unstressed conditions to identify role of mutations in gene expression.

2010-07-15 | E-GEOD-20943 | biostudies-arrayexpress

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