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Acquired colistin resistance strains isolated from ICU patients

ABSTRACT: Acquired colistin resistance strains isolated from ICU patients

PROVIDER: PRJEB34028 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3484410_1.fastq.gz	Fastqsanger.gz
	ERR3484410_2.fastq.gz	Fastqsanger.gz
	ERR3484401_1.fastq.gz	Fastqsanger.gz
	ERR3484401_2.fastq.gz	Fastqsanger.gz
	ERR3484411_1.fastq.gz	Fastqsanger.gz

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Project description:We found that the antibiotic colistin acts synergistically with antifungals of the echinocandin class (e.g. aminocandin) on C. albicans cells. In order to elucidate the mode of action of colistin in fungi we performed microarray analysis of samples treated with only aminocandin (0.00125µg/ml) or treated with aminocandin (0.00125µg/ml) and colistin (5µg/ml). We compared: (A). untreated cells to cells treated with aminocandin only; (B). cells treated with aminocandin to cells treated with aminocandin and colistin (which is the focus of this experiment). By comparing those datasets it should be possible to identify genes differentially expressed in response to aminocandin and in response to both drugs. And subsequently to be able to interpret where in the cell colistin acts. (See related experiment in ArrayExpress: E-MEXP-3437 for comparison between untreated cells vs cells treated with aminocandin only.)

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Proteomic changes of Klebsiella pneumoniae in response to colistin treatment and crrB mutation-mediated colistin resistance

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