Project description:Tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in an individual, we analyzed multiple tumors from men with disseminated prostate cancer through whole-exome sequencing, array comparative genomic hybridization (CGH) and RNA transcript profiling, and we compared the genomic diversity within and between individuals.

2016-02-16 | GSE77930 | GEO

Alectoria sarmentosa strain:MAF-Lich 21536 | isolate:MAF-Lich 21536

Project description:Alectoria sarmentosa strain:MAF-Lich 21536 | isolate:MAF-Lich 21536 Genome sequencing and assembly

| PRJNA588068 | ENA

Cryptic diversity in Cytherissa ostracods

Project description:Cryptic diversity and speciation in endemic Cytherissa (Ostracoda, Crustacea) from Lake Baikal

| PRJEB21475 | ENA

Differences in Genetic Diversity of Tick-Borne Flaviviruses

Project description:There are very few studies exploring the genetic diversity of tick-borne encephalitis complex viruses. Most of the viruses have been sequenced using capillary electrophoresis, however, very few viruses have been analyzed using deep sequencing to look at the genotypes in each virus population. In this study, different viruses and strains belonging to the tick-borne encephalitis complex were sequenced and genetic diversity was analyzed. Shannon entropy and single nucleotide variants were used to compare the viruses. Then genetic diversity was compared to the phylogenetic relationship of the viruses.

2023-12-04 | E-MTAB-12112 | biostudies-arrayexpress

Cryptic diversity in European bats.

Project description:Different species of bat can be morphologically very similar. In order to estimate the amount of cryptic diversity among European bats we screened the intra- and interspecific genetic variation in 26 European vespertilionid bat species. We sequenced the DNA of subunit 1 of the mitochondrial protein NADH dehydrogenase (ND1) from several individuals of a species, which were sampled in a variety of geographical regions. A phylogeny based on the mitochondrial (mt) DNA data is in good agreement with the current classification in the family. Highly divergent mitochondrial lineages were found in two taxa, which differed in at least 11% of their ND1 sequence. The two mtDNA lineages in Plecotus austriacus correlated with the two subspecies Plecotus austriacus austriacus and Plecotus austriacus kolombatovici. The two mtDNA lineages in Myotis mystacinus were partitioned among two morphotypes. The evidence for two new bat species within Europe is discussed. Convergent adaptive evolution might have contributed to the morphological similarity among distantly related species if they occupy similar ecological niches. Closely related species may differ in their ecology but not necessarily in their morphology. On the other hand, two morphologically clearly different species (Eptesicus serotinus and Eptesicus nilssonii) were found to be genetically very similar. Neither morphological nor mitochondrial DNA sequence analysis alone can be guaranteed to identify species.

| S-EPMC1088815 | biostudies-other

Cryptic diversity in Nearctic Lasius ants

Project description:Integrative taxonomy reveals cryptic diversity in North American Lasius ants, and an overlooked introduced species

| PRJEB49643 | ENA