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FieldSeq - Whole genome sequencing of PPRV

ABSTRACT: Field-adapted full genome sequencing of peste-des-petits-ruminants virus using Nanopore sequencing

PROVIDER: PRJEB35549 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR4029700_1.fastq.gz	Fastqsanger.gz
	ERR4029701_1.fastq.gz	Fastqsanger.gz
	ERR4029692_1.fastq.gz	Fastqsanger.gz
	ERR4029702_1.fastq.gz	Fastqsanger.gz
	ERR4029693_1.fastq.gz	Fastqsanger.gz

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Alteration in m6A methylome of goat lung under PPRV infection

Project description:We report the application of MeRIP-seq (m6A-specific methylated RNA immunoprecipitation) for m6A site profiling of lung tissue under Peste des petits ruminants virus (PPRV) infection.

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miRNAs expression profile in goat peripheral blood mononuclear cells (PBMCs) infected with Nigeria 75/1 vaccine virus

Project description:Peste des petits ruminants virus (PPRV) belongs to the genus Morbillivirus that causes an acute and highly contagious disease in goats and sheep. Virus infection can trigger the change in the cellular microRNA (miRNA) expression profile, which play important post-transcriptional regulatory roles in gene expression and can greatly influence viral replication and pathogenesis. Here, we employed deep sequencing technology to determine cellular miRNAs expression profile in goat peripheral blood mononuclear cells (PBMCs) infected with Nigeria 75/1 vaccine virus, a widely used vaccine strain for mass vaccination programs against Peste des petits ruminants (PPR). Expression analysis demonstrated that PPRV infection can elicit 316 significantly differentially expressed (DE) miRNAs including 103 known and 213 novel miRNAs candidates in infected PBMCs at 24 hours post-infection as compared with mock control. Target prediction and functional analysis of these DEmiRNAs revealed significant enrichment for several signaling pathways including TLR signaling pathways, PI3K-Akt, endocytosis, viral carcinogenesis, and JAK-STAT signaling pathways. This study provides a valuable basis for further investigation on the roles of miRNAs in PPRV replication and pathogenesis.

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Project description:Sequencing of peste des petits ruminants virus strains

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Project description:Viruses have evolved numerous strategies to impair immunity so that they can replicate more efficiently, such as the immunosuppressive effects of Morbillivirus infection. In the present work we hypothesized that the highly contagious morbillivirus Peste des Petits Ruminants virus (PPRV) could target monocytes and dendritic cells (DC) to contribute to the immunosuppressive effects produced by the infection. Monocytes isolated from healthy sheep donor, a natural host of the disease, could be infected by PPRV and this impaired the differentiation and phagocytic ability of immature monocyte-derived DC (MoDC). Ovine MoDC could be productively infected by PPRV, and this drastically reduced MoDC capacity to activate allogeneic T cell responses. Transcriptomic analysis of infected MoDC indicated that several tolerogenic DC signature genes were upregulated upon PPRV infection.

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Project description:Complete Genome Sequence of a Lineage IV Peste des Petits Ruminants Virus from Turkey, 2018.

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Contrasting gene expression profiles of monocytes and lymphocytes from Peste-des-petits-ruminants virus infected goats

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