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Safety assessment of the Bacteroides uniformis CECT 7771

ABSTRACT: Faecal microbiota assessment on rats under sub-chronical oral administration of Bacteroides uniformis CECT 7771

PROVIDER: PRJEB35764 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3760040.fastq.gz	Fastqsanger.gz
	ERR3760050.fastq.gz	Fastqsanger.gz
	ERR3760060.fastq.gz	Fastqsanger.gz
	ERR3760070.fastq.gz	Fastqsanger.gz
	ERR3760041.fastq.gz	Fastqsanger.gz

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Safety Assessment of <i>Bacteroides Uniformis</i> CECT 7771, a Symbiont of the Gut Microbiota in Infants.

Project description:The formulation of next-generation probiotics requires competent preclinical studies to show their efficacy and safety status. This study aims to confirm the safety of the prolonged oral use of Bacteroides uniformis CECT 7771, a strain that protected against metabolic disorders and obesity in preclinical trials, in a sub-chronic 90 day trial in animals. The safety assessment was conducted in male and female Wistar rats (n = 50) administered increasing doses (108 CFU/day, 109 CFU/day, or 1010 CFU/day) of B. uniformis CECT 7771, 1010 CFU/day of B. longum ATCC 15707T, which complies with the qualifying presumption of safety (QPS) status of the EU, or vehicle (placebo), as the control. Pancreatic, liver, and kidney functions and cytokine concentrations were analyzed. Bacterial translocation to peripheral tissues was evaluated, and colon integrity was investigated histologically. No adverse metabolic or tissue integrity alterations were associated with treatments; however, alanine aminotransferase levels and the ratio of anti-inflammatory to pro-inflammatory cytokines in serum indicated a potentially beneficial role of B. uniformis CECT 7771 at specific doses. Additionally, the microbial community structure was modified by the interventions, and potentially beneficial gut bacteria were increased. The results indicated that the oral consumption of B. uniformis CECT 7771 during a sub-chronic 90 day study in rats did not raise safety concerns.

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Genome analysis of the Bacteroides uniformis CECT 7771.

Project description:This study aims the genome sequencing of the symbiont Bacteroides uniformis CECT 7771 isolated from infant feces as well as the characterization of its genome response to different carbon sources through a RNA seq approach.

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Transcriptome profiling of Lactococcus lactis subsp. cremoris CECT 8666 in response to agmatine

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Transcriptome profiling of Lactococcus lactis subsp. cremoris CECT 8666 in response to agmatine

Project description:The goal was to determine the effect of agmatine on the trancriptional profile of L. lactis CECT 8666 strain. For that we compared the expression profile of L. lactis CECT 8666 cells grown in culture medium supplemented with 20 mM agmatine with the expression profile of L. lactis CECT 8666 cells grown in culture medium without agmatine. L. lactis CECT 8666 cells grown in GalM17 medium (reference) compared to L. lactis CECT 8666 cells grown in GalM17 medium supplemented with 20 mM agmatine (test).

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