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TRAP-seq of mouse astrocytes involved in central nervous system remyelination

ABSTRACT: TRAP-seq of mouse astrocytes involved in central nervous system remyelination

PROVIDER: PRJEB39118 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4299700_1.fastq.gz	Fastqsanger.gz
	ERR4299700_2.fastq.gz	Fastqsanger.gz
	ERR4299701_1.fastq.gz	Fastqsanger.gz
	ERR4299701_2.fastq.gz	Fastqsanger.gz
	ERR4299702_1.fastq.gz	Fastqsanger.gz

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TRAP-seq of mouse astrocytes involved in central nervous system remyelination

Project description:Remyelination failure contributes to axonal dysfunction in neurodegenerative disorders. But whether astrocytes, the most abundant glial cell type in demyelinated lesions, support or impede remyelination is controversial. Following focal demyelinated lesions of the mouse corpus callosum induced with the myelin toxin lysolecithin, we used TRAP (translational ribosome affinity purification) sequencing to isolate and sequence ribosome-associated mRNAs which are being actively translated in astrocytes, and studied how the responses and molecular mechanisms in astrocytes are linked to remyelination.

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