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RNA-seq of Candida parapsilosis CLIB 214 (CBS 604) grown on different hydroxyaromatic substrates

ABSTRACT: RNA-seq of Candida parapsilosis CLIB 214 (CBS 604) grown on different hydroxyaromatic substrates

PROVIDER: PRJEB39891 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4467220_1.fastq.gz	Fastqsanger.gz
	ERR4467220_2.fastq.gz	Fastqsanger.gz
	ERR4467221_1.fastq.gz	Fastqsanger.gz
	ERR4467221_2.fastq.gz	Fastqsanger.gz
	ERR4467222_1.fastq.gz	Fastqsanger.gz

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RNA-seq of Candida parapsilosis CLIB 214 (CBS 604) grown on different hydroxyaromatic substrates

Project description:Candida parapsilosis CLIB 214 (CBS 604) was grown on synthetic media containing hydroxyaromatic compounds as a sole carbon source. The cells cultivated in medium containing galactose were used as a control. Total RNA was isolated using hot acid phenol extraction. A TruSeq stranded mRNA library was sequenced on an Illumina NovaSeq 6000 system.

2021-10-02 | E-MTAB-9443 | biostudies-arrayexpress

RNA-seq of knock-out mutants of Candida parapsilosis CLIB 214 (CBS 604)

Project description:This study compares gene expression in three strains (CPL2H1, CPL2H1 gtf1/gtf1 and CPL2H1 otf1/otf1) with the genetic background of Candida parapsilosis CLIB 214 (CBS 604). Total RNA was isolated using hot acid phenol extraction. A TruSeq stranded mRNA library was sequenced on an Illumina NovaSeq 6000 system.

2021-10-02 | E-MTAB-9442 | biostudies-arrayexpress

RNA-seq of knock-out mutants of Candida parapsilosis CLIB 214 (CBS 604)

Project description:RNA-seq of knock-out mutants of Candida parapsilosis CLIB 214 (CBS 604)

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Project description:Candida parapsilosis CBS 604 (CLIB 214, ATCC 22019, NRRL Y-12969) genome sequencing

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Transcriptional landscape of Candida parapsilosis cells assimilating hydroxyaromatic substrates

Project description:The pathogenic yeast Candida parapsilosis can utilize a wide range of hydroxyaromatic substrates as sole carbon sources through the 3-oxoadipate pathway (3-OAP) and the gentisate pathway (GP). It was previously established that the genes coding for the components of these pathways are arranged in two metabolic gene clusters. In this study we investigated the transcriptional regulation of these gene clusters, as well as the changes in major metabolic pathways in cells assimilating hydroxyaromates. First, using second and third generation sequencing technologies we determined the genomic sequence of the C. parapsilosis CLIB214 strain. This was then used as a platform to a transcriptomic and proteomic analysis of CLIB214 cells utilizing different substrates of the 3-OAP and the GP. Our results show that the activation of both pathways leads to upregulation of genes related to β-oxidation of fatty acids, glyoxylate cycle, metabolism of amino acids and the biogenesis of peroxisomes. In spite of the similar overall response, we identified quite the difference in gene expression between cells assimilating individual aromatic substrates and surprisingly, not only when comparing the substrates of the 3OAP with the GP substrates, but also between substrates channelled through the same pathway. Moreover, with the phenotype analysis of knockout mutants, we showed evidence that transcription factors Otf1 and Gtf1 function as transcriptional activators of genes coding for core components of the 3-OAP and GP, respectively.

2022-02-01 | PXD024608 | Pride

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Project description:Investigation of centromeres in the pathogenic yeast Candida parapsilosis, shows that the location of two centromeres are polymorphic within this species. The centromeres consist of large inverted repeats (IRs), surrounding unique sequences. New (neo) centromeres have emerged in one C. parapsilosis isolate even though the original CEN location is undamaged. The neocentromeres do not contain IRs, and have no obvious sequence features.

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2011-11-30 | GSE32714 | GEO

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