Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Klebsiella phage vB_KvM-Eowyn, whole genome

ABSTRACT: Klebsiella phage vB_KvM-Eowyn

PROVIDER: PRJEB40131 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR4557760_1.fastq.gz	Fastqsanger.gz
	ERR4557760_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Klebsiella phage vB_KppS-Raw, whole genome

Project description:Klebsiella phage vB_KppS-Raw

| PRJEB40132 | ENA

Klebsiella phage vB_KppS-Eggy, whole genome

Project description:Klebsiella phage vB_KppS-Eggy

| PRJEB40146 | ENA

Phage-Antibiotic Combinations Against Klebsiella pneumoniae

Project description:hvKP ATCC43816 and its lytic phage H5 were employed as a phage-antibiotic combination model. Based on the comprehensive characterization of phages, including cryo-electron microscopy, we evaluated the synergic effect of H5 on bacterial killing in vitro when combined with multiple antibiotics, and analyzed the advantages of phage-antibiotic combinations from an evolutionary perspective and proposes a novel PAS mechanism by using ceftazidime as an example.

2023-09-14 | GSE237490 | GEO

Rapid design of bacteriophage cocktails to suppress the burden and virulence of gut-resident carbapenem-resistant Klebsiella pneumoniae

Project description:Antibiotic use can lead to expansion of multi-drug resistant pathobionts within the gut microbiome that can cause life-threatening infections. Selective alternatives to conventional antibiotics are in dire need. Here, we describe a Klebsiella PhageBank that enables the rapid design of antimicrobial bacteriophage cocktails to treat multi-drug resistant Klebsiella pneumoniae. Using a transposon library in carbapenem-resistant K. pneumoniae, we identified host factors required for phage infection in major Klebsiella phage families. Leveraging the diversity of the PhageBank and experimental evolution strategies, we formulated combinations of phages that minimize the occurrence of phage resistance in vitro. Optimized bacteriophage cocktails selectively suppressed the burden of multi-drug resistant K. pneumoniae in the mouse gut microbiome and drove bacterial populations to lose key virulence factors that act as phage receptors. Further, phage-mediated diversification of bacterial populations in the gut enabled co-evolution of phage variants with higher virulence and a broader host range. Altogether, the Klebsiella PhageBank represents a roadmap for both phage researchers and clinicians to enable phage therapy against a critical multidrug-resistant human pathogen.

2024-10-01 | GSE272297 | GEO

Klebsiella phage K11

Project description:Klebsiella phage K11 overview

| PRJNA69753 | ENA

Klebsiella pneumoniae phage

Project description:Klebsiella pneumoniae phage overview

| PRJNA981633 | ENA

Klebsiella phage K11

Project description:Klebsiella phage K11 Genome sequencing

| PRJNA29825 | ENA

Klebsiella phage P13

Project description:Klebsiella phage P13 Genome sequencing