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AMR in Danish Campylobacter

ABSTRACT: Prediction of Antimicrobial Resistance in clinical Campylobacter jejuni Isolates from Whole-Genome Sequencing Data

PROVIDER: PRJEB40238 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4570290_1.fastq.gz	Fastqsanger.gz
	ERR4570290_2.fastq.gz	Fastqsanger.gz
	ERR4570300_1.fastq.gz	Fastqsanger.gz
	ERR4570300_2.fastq.gz	Fastqsanger.gz
	ERR4570310_1.fastq.gz	Fastqsanger.gz

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Array-based comparative genomics of Campylobacter jejuni sheep abortion isolates (Part 1)

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Adaptive mechanism of Campylobacter jejuni to treatment with a novel CmeABC efflux pump inhibitor (-)-α-Pinene

Project description:Objectives: The aim of the study was to characterize (-)-α-Pinene, which is one of the chemical constituents of Alpinia katsumadai seed essential oil responsible for its resistance modulatory activity in Campylobacter jejuni. Methods: Broth microdilution method was used to evaluate the antimicrobial and resistance modulatory potential of (-)-α-Pinene and ethidium bromide accumulation assay to determine its efflux-inhibitory activity in subinhibitory concentration. The target efflux system was identified using knock-out mutants in several efflux related genes. Furthermore, the influence of subinhibitory concentration of (-)-α-Pinene on C. jejuni NCTC 11168 was investigated using microarray technology in order to elucidate the adaptive mechanism of bacteria to treatment with this phytochemical. Knock-out mutants of key adaptation genes were constructed and their role in adaptation to several stress factors, including (-)-α-Pinene, different osmolites and pH, was investigated using Biolog phenotypical microarrays and CFU counts. Results: (-)-α-Pinene was confirmed as highly efficient Campylobacter jejuni resistance modulator, due to its efflux inhibitory activity, which was significantly higher compared to reference inhibitors CCCP and reserpine. The CmeABC along with newly characterized CmeI (Cj1687) was confirmed as its main target efflux system. The transcriptional analysis indicated that the heat shock regulators HspR and HrcA are the main transcription regulators involved in adaptation to (-)-α-Pinene treatment. Conclusions: (-)-α-Pinene is a novel CmeABC and CmeI efflux inhibitor, which evokes the heat shock response in Campylobacter jejuni.

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