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3' UTR RNA-seq of CRISPR-edited human EGFR-mutant PC9 lung cancer cell lines after osimertinib treatment

ABSTRACT: 3' UTR RNA-seq of CRISPR-edited human EGFR-mutant PC9 lung cancer cell lines after osimertinib treatment

PROVIDER: PRJEB41841 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR4972440.fastq.gz	Fastqsanger.gz
	ERR4972441.fastq.gz	Fastqsanger.gz
	ERR4972442.fastq.gz	Fastqsanger.gz
	ERR4972443.fastq.gz	Fastqsanger.gz
	ERR4972444.fastq.gz	Fastqsanger.gz

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3' UTR RNA-seq of CRISPR-edited human EGFR-mutant PC9 lung cancer cell lines after osimertinib treatment

Project description:Human EGFR-mutant lung adenocarcinoma cells (PC9) were engineered using CRISPRv2 systemt to knock-out MAVS or STING to assess impact on transcriptomic response following osimertinib treatment

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Differential expression genes between PC9 cells and osimertinib resistant PC9OR cells

Project description:To investigate the possible resistant mechanism to osimertinib, PC9 cells and their derived osimertinib-resistant PC9OR cells were sequenced using illumina HiSeq. We then performed gene expression profiling analysis using data obtained from RNA-seq of PC9 cells and their derived PC9OR cells.

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3' UTR RNA-sequencing of human EGFR-mutant lung cancer cell lines under osimertinib treatment

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Project description:Drug tolerant persister cells of EGFR-mutant PC9 cell lines surviving treatment with kinase inhibitor combination. Cells were treated with combination of erlotinib, osimertinib, trametinib and dasatinib and surviving cells were harvested for RNA extraction. 3' UTR RNA-seq profiles were compared to parental control cells and to outgrowing cells after treatment had been removed

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