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Mycobacterium africanum and Mycobacterium orygis in Norway

ABSTRACT: Whole-genome sequencing of all M. africanum and M. orygis isolates identified in Norway 2010-2020.

PROVIDER: PRJEB43202 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	ERR5336150_1.fastq.gz	Fastqsanger.gz
	ERR5336150_2.fastq.gz	Fastqsanger.gz
	ERR5336160_1.fastq.gz	Fastqsanger.gz
	ERR5336160_2.fastq.gz	Fastqsanger.gz
	ERR5336170_1.fastq.gz	Fastqsanger.gz

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Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway.

Project description:BackgroundThe aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway.MethodsWhole-genome sequences (WGS) were generated for all (n = 29) available clinical isolates received at the Norwegian National Reference Laboratory for Mycobacteria (NRL) and identified as MAF in Norway, in the period 2010-2020. Phylogenetic analyses were performed.ResultsThe analyses indicated several imports of MAF lineage 6 from both East and West African countries, whereas MAF lineage 5 was restricted to patients with West African connections. We also find evidence for transmission of MAF in Norway. Finally, our analyses revealed that a group of isolates from patients originating in South Asia, identified as MAF by means of a commercial line-probe assay, in fact belonged to Mycobacterium orygis.ConclusionsMost MAF cases in Norway are the result of import, but transmission is occurring within Norway.

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