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Contact precautions: MRSA and VRE

ABSTRACT: Does high adherence to contact precautions lead to low in-hospital transmission of multidrug resistant organisms in the endemic setting?

PROVIDER: PRJEB43633 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR5462722_1.fastq.gz	Fastqsanger.gz
	ERR5462722_2.fastq.gz	Fastqsanger.gz
	ERR5462723_1.fastq.gz	Fastqsanger.gz
	ERR5462723_2.fastq.gz	Fastqsanger.gz
	ERR5462724_1.fastq.gz	Fastqsanger.gz

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VRE Control study

Project description:Impact of single room contact precautions on hospital-acquisition and transmission of vancomycin-resistant enterococci in a high-risk setting

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Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins

Project description:Most bacteria are in fierce competition with other species for limited nutrients. Some bacteria can kill nearby cells by secreting bacteriocins, a diverse group of proteinaceous antimicrobials. However, bacteriocins are typically freely diffusible, and so of little value to planktonic cells in aqueous environments. Here, we identify an atypical two-protein bacteriocin in the gamma-proteobacterium Caulobacter crescentus that is retained on the surface of producer cells where it mediates cell contact-dependent killing. The bacteriocin-like proteins CdzC and CdzD harbor glycine-zipper motifs, often found in amyloids, and CdzC forms large, insoluble aggregates on the surface of producer cells. These aggregates can drive contact-dependent killing of other organisms, or Caulobacter cells not producing the CdzIE immunity protein. The Cdz system uses a type I secretion system and is unrelated to previously described contact-dependent inhibition systems. However, Cdz-like systems are found in many bacteria, suggesting that this form of contact-dependent inhibition is common.

2017-05-03 | GSE96582 | GEO

NZ Household Contact Meningococci

Project description:NZ Household Contact Meningococci

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Proteomic analyses of Mycobacterium tuberculosis associated sputum and plasma

Project description:Tuberculosis (TB) remains one of the world’s major infectious diseases affecting nations with limited public health resources. Multidrug resistance development has seriously compromised therapeutic treatment choices. The pathology of latent TB shows evidence of a reservoir of Mycobacterium tuberculosis (Mtb) in the lungs of affected individuals. If the pathogen is contained by the immune system, no overt disease symptoms occur. The environmental and internal triggers leading to disease reactivation are not well understood. Proteomic investigations of blood plasma and sputum derived from subjects with active TB versus latent TB versus healthy individuals may yield new biomarkers and, when surveying larger longitudinally monitored cohorts, may discriminate infection outcomes in an endemic setting.

2021-05-26 | PXD012412 | Pride

VRE Outbreaks in Switzerland

Project description:Patients exposed to vancomycin resistant enterococci (VRE) during in-hospital outbreaks in a low endemic setting: who is at risk for acquisition? Report of three outbreaks with VRE in Switzerland, 2018-2019

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Erebia Contact zone project

Project description:Secondary contact in Erebia butterflies

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NZ household contact meningococci

Project description:NZ household contact meningococci: RNAseq

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Not too close! impact of roommate status on MRSA and VRE colonization and contamination in Nursing Homes.

Project description:Multiple room occupancy is common in Nursing Homes (NHs), and its role in transmission of antibiotic-resistant pathogens is unclear. We investigated prevalence of patient colonization and environmental contamination with vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) in NH roommates, compared it with expected prevalence, and determined specific body and environmental sites that may act as sources of roommate colonization. Roommate contamination was associated with index patient's colonization (relative risk (RR): 2.57 (95% CI 1.04-6.37)) for MRSA, and index patient's immediate environment contamination for VRE (RR: 3.60 (95% CI 1.59-8.12)). When specific index patient sites associated with roommate colonization were investigated, the side table (Fisher's p = 0.029 and 0.047 for VRE and MRSA, respectively) and the nurse call button (p = 0.001 and 0.052) stood out, together with patient hands in the case of VRE (p = 0.026). Future studies should be carried out to establish whether these sites should be a specific target of infection prevention campaigns in NHs with multiple occupancy rooms.

| S-EPMC8258944 | biostudies-literature

Rate of nosocomial MRSA transmission evaluated via contact screening.

Project description:BackgroundThe prevention of methicillin-resistant S. aureus (MRSA) transmission in the healthcare setting is a priority in Infection Control practices. A cornerstone of this policy is contact tracing of nosocomial contacts after an unexpected MRSA finding. The objective of this retrospective study was to quantify the rates of MRSA transmission in different clinical settings.MethodsThis multi-centre study included MRSA contact screening results from two regional hospitals and one academic hospital. MRSA contact tracing investigations from 2000 until 2019 were reviewed and post-contact screening results were included of index patients with an MRSA-positive culture and their unprotected contacts. Available typing results were used to rule out incidental findings.ResultsOf 27,377 contacts screened after MRSA exposure, 21,488 were Health Care Workers (HCW) and 4816 patients. Post-contact screening was initiated for a total of 774 index cases, the average number of screened contacts per index case was 35.7 (range 1 to 640). MRSA transmission was observed in 0.15% (41) of the contacts, 19 (0.09%) HCW and 22 (0.46%) patients. The number needed to screen to detect one MRSA transmission was 667. The highest risk of MRSA transmission occurred during patient-to-patient contacts, with transmission rates varying from 0.32 to 1.32% among the participating hospitals. No transmissions were detected in HCW (n=2834) in the outpatient setting, and the rate of transmissions among HCW contacts on the wards was 0.13% (19 of 15,874). Among 344 contacts of patients with contact precautions, no transmissions were detected.ConclusionsReconsidering current MRSA contact tracing practices may lead to a more targeted approach with a lower number needed to screen.

| S-EPMC11348754 | biostudies-literature

Epithelial cells in contact with bacterial supernatant

Project description:Epithelial cells were in contact with bacteria supernatant during different times of incubation. time course supernatant 10 % MM39

2004-08-26 | E-GEOD-1704 | biostudies-arrayexpress

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