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Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis

ABSTRACT: Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis

PROVIDER: PRJEB4606 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR341301_1.fastq.gz	Fastqsanger.gz
	ERR341301_2.fastq.gz	Fastqsanger.gz
	ERR341302_1.fastq.gz	Fastqsanger.gz
	ERR341302_2.fastq.gz	Fastqsanger.gz

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Diverse vaginal microbiomes in reproductive-age women with vulvovaginal candidiasis.

Project description:Vulvovaginal candidiasis (VVC) is one of the most prevalent vaginal infectious diseases, and there are controversial reports regarding the diversity of the associated vaginal microbiota. We determined the vaginal microbial community in patients with VVC, bacterial vaginosis (BV), and mixed infection of VVC and BV using Illumina sequencing of 16S rRNA tags. Our results revealed for the first time the highly variable patterns of the vaginal microbiome from VVC patients. In general, the alpha-diversity results of species richness and evenness showed the following order: normal control < VVC only < mixed BV and VVC infection < BV only. The beta-diversity comparison of community structures also showed an intermediate composition of VVC between the control and BV samples. A detailed comparison showed that, although the control and BV communities had typical patterns, the vaginal microbiota of VVC is complex. The mixed BV and VVC infection group showed a unique pattern, with a relatively higher abundance of Lactobacillus than the BV group and higher abundance of Prevotella, Gardnerella, and Atopobium than the normal control. In contrast, the VVC-only group could not be described by any single profile, ranging from a community structure similar to the normal control (predominated with Lactobacillus) to BV-like community structures (abundant with Gardnerella and Atopobium). Treatment of VVC resulted in inconsistent changes of the vaginal microbiota, with four BV/VVC samples recovering to a higher Lactobacillus level, whereas many VVC-only patients did not. These results will be useful for future studies on the role of vaginal microbiota in VVC and related infectious diseases.

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