Project description:Comparative genomic hybridisation of genomic DNA from avian species to the Roche NimbleGen chicken whole genome oligonucleotide array. The purpose was to identify copy number variants between the given species and chicken. The starting material was blood or feather pulp from a variety of bird species, from which we performed DNA extractions.
Project description:Chickens are the most abundant agricultural animals globally, with controlling abdominal fat deposition (AFD) being a key objective in poultry breeding. While GWAS can identify genetic variants associated with AFD traits, the precise roles and mechanisms of these variants remain largely unclear. This study used two distinct chicken lines, selectively bred for differing AFD, as experimental models. Through the integration of genomic, epigenomic, 3D genomic, and transcriptomic data, a comprehensive chromatin 3D regulatory network map was developed to reveal the genetic regulatory mechanisms that influence AFD traits.
