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IdTheAtra

ABSTRACT: Thecophora atra

PROVIDER: PRJEB51036 | ENA |

REPOSITORIES: ENA

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Dataset's files

Source:

			Action	DRS
		Other
	ERR10123684_1.fastq.gz	Fastqsanger.gz
	ERR10123684_2.fastq.gz	Fastqsanger.gz
	ERR8702824_1.fastq.gz	Fastqsanger.gz
	ERR8702824_2.fastq.gz	Fastqsanger.gz

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Thecophora atra

Project description:Thecophora atra overview

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idTheAtra2 alternate haplotype

Project description:Thecophora atra genome assembly, idTheAtra2, alternate haplotype

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idTheAtra2.Spiroplasma_sp_1

Project description:Spiroplasma endosymbiont of Thecophora atra genome assembly, idTheAtra2.Spiroplasma_sp_1

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idTheAtra2.Tisiphia_sp_1

Project description:Candidatus Tisiphia endosymbiont of Thecophora atra genome assembly, idTheAtra2.Tisiphia_sp_1

| PRJEB74799 | ENA

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [ChIP-Seq]

Project description:All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming, inhibitors of LSD1/KDM1 demethylase including tranylcypromine (TCP) unlocked the ATRA-driven therapeutic response in non-APL AML. LSD1 inhibition did not lead to an increase in genome-wide H3 lysine4 dimethylation (H3K4me2) but did increase H3K4me2 and expression of myeloid differentiation-associated genes. Importantly, treatment with ATRA plus TCP dramatically diminished engraftment of primary human AML cells in vivo in NOD.SCID mice, suggesting that ATRA in combination with TCP may target leukemia-initiating cells. Furthermore, initiation of ATRA plus TCP co-treatment 15 days post-engraftment of human AML cells in NOD.SCID gamma mice also revealed the ATRA plus TCP drug combination to have a potent anti-leukemic effect, which was superior to treatment with either drug alone. These data identify LSD1 as a therapeutic target and strongly suggest that it may contribute to AML pathogenesis by inhibiting the normal pro-differentiative function of ATRA, paving the way for novel combinatorial therapies of AML. ChIP-seq was used to study the effects of ATRA, TCP and ATRA/TCP treatment on H3K4 dimethylation. In addition to the three treatment samples, two reference samples were processed: (i) An untreated sample using the same anti-H3K4me2 antibody and an untreated sample using IgG. These five sequencing experiments were conducted using HL-60 cells and TEX cells, leading to 10 ChIP-seq samples in total.

2012-03-14 | E-GEOD-34725 | biostudies-arrayexpress

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [ChIP-Seq]

2012-03-14 | GSE34725 | GEO

Comprehensive analysis of genome-wide transcriptome modification during neuronal differentiation of mouse embryonic stem cells by all-trans retinoic acid

Project description:Total RNA from 4 sample which are control and differentiation stage after treated ATRA with 4days (Embryonic body, Embryonic body + ATRA (0D), Embryonic body + ATRA (6D), Embryonic body + ATRA (10D))

2017-03-01 | GSE93581 | GEO

CAMKK and CRAC channel regulate autophagy, differentiation and apoptosis in acute promylocytic leukemia cells treated by ATRA

Project description:ATRA is an active metabolite of vitamin A that is frequently used for the treatment of acute promyelocytic leukemia (APL) patients. Despite the success of this treatment, some APL patients are refractory or relapse. This emphasis the need for new therapeutic strategies aiming to improve the anti-cancer effect of ATRA. We and other have previously shown that autophagy is activated during ATRA-induced granulocytic differentiation of acute promyelocytic leukemia cells. Although the transcription effect of ATRA on autophagy has been well-documented, little is known on the post-transcription/ post-translational regulation autophagy in response to ATRA. Given the importance of calcium ions in the control of autophagy, we hypothesized that calcium ions are involved in the initiation of autophagy by ATRA in APL cells. We thus examined how ATRA regulate intracellular calcium and sense perturbation of Ca2+ responses to autophagy, differentiation and cell death in APL cells.

2021-11-24 | PXD026904 | Pride

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