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Cutibacterium acnes isolates from severe infections

ABSTRACT: Cutibacterium acnes isolates from severe infections

PROVIDER: PRJEB52145 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR9559540_1.fastq.gz	Fastqsanger.gz
	ERR9559540_2.fastq.gz	Fastqsanger.gz
	ERR9559550_1.fastq.gz	Fastqsanger.gz
	ERR9559550_2.fastq.gz	Fastqsanger.gz
	ERR9559560_1.fastq.gz	Fastqsanger.gz

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Molecular typing and functional profiling of acne-derived Cutibacterium acnes isolates reveal determinants of skin inflammation

Project description:Cutibacterium acnes (C. acnes) is a ubiquitous skin commensal bacterium that is generally well tolerated by the immune system. Different strain-types of C. acnes have been reported to be enriched on patients with acne. To understand if these strain-types contribute to skin inflammation, we generated a library of over 200 C. acnes isolates from skin swabs of healthy and acne subjects and assessed their strain-level identity and inflammatory potential. Phylotype II K-type strains were more frequent on healthy and acne non-lesional skin compared to lesional. Phylotype IA-1 C-type strains were dominant on acne lesional skin but absent from healthy. Measurement of host cytokine responses from C. acnes supernatant revealed neither strain-type nor skin-type association predicted inflammatory potential. However, differential proinflammatory responses were induced from identical strain-types, but these differences were not attributable to protease, short chain fatty acid or porphyrin production. Instead, whole genome sequencing revealed the presence of a linear plasmid in high inflammatory strain-types. Intradermal injection of C. acnes in mouse skin revealed a plasmid-associated inflammatory response in dermal fibroblasts, revealed by single-cell RNA sequencing. We conclude that C. acnes strain-type is not sufficient to predict inflammation but other virulence factors including a plasmid may contribute to disease.

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