ABSTRACT: EMG produced TPA metagenomics assembly of PRJNA760651 data set (Exploring the possible link between the gut microbiome and fat deposition in pigs).
Project description:We performed DNA methylation analysis of the longissimus dorsi (LD) muscle between two development stages (120 and 240 days after birth) in Laiwu pigs, an indigenous fatty pig breed in North China. This study provides a reference for exploring methylation regulation mechanisms affecting fat deposition in obese pigs.
2017-01-13 | GSE93563 | GEO
Project description:EMG produced TPA metagenomics assembly of PRJNA389749 data set (Caecal Metagenome of Pigs).
Project description:Excessive fat deposition can trigger metabolic diseases, and it is crucial to identify factors that can break the link between fat deposition and metabolic diseases. Healthy obese Laiwu pigs (LW) are high in fat content but resistant to metabolic diseases. In this study, we compared the fecal microbiome, fecal and blood metabolome, and genome of LW and Lulai pigs (LU) to identify factors that can block the link between fat deposition and metabolic diseases. Our results show significant differences in Spirochetes and Treponema, which are involved in carbohydrate metabolism, between LW and LU. The fecal and blood metabolome composition was similar, and some anti-metabolic disease components of blood metabolites were different between the two breeds of pigs. The predicted differential RNA is mainly enriched in lipid metabolism and glucose metabolism, which is consistent with the functions of differential microbiota and metabolites. The down-regulated gene RGP1 is strongly negatively correlated with Treponema. Our omics data would provide valuable resources for further scientific research on healthy obesity in both human and porcine.
2023-04-20 | MTBLS3977 | MetaboLights
Project description:EMG produced TPA metagenomics assembly of PRJNA986291 data set (CForBio.metagenome).
| PRJEB71756 | ENA
Project description:EMG produced TPA metagenomics assembly of PRJNA639280 data set (v).
| PRJEB72785 | ENA
Project description:EMG produced TPA metagenomics assembly of PRJEB30246 data set (Metagenomic_analysis_nasopharyngeal_colonisation).
Project description:The present work emplyed pigs as an animal model for recognition of molecular processes associated with fat deposition. The transcriptomic changes dependent on fat content were showed at the fat and liver levels. In the experiment Złotnicka White pigs were used that were not under selection pressure, because they are included in to National Preservation Program.
2020-10-30 | GSE160436 | GEO
Project description:EMG produced TPA metagenomics assembly of the PRJEB25223 data set (Longitudinal_Nasopharyngeal_Microbiome_Dynamics_in_Infants_from_the_Maela_ARI_Birth_Cohort).
| PRJEB33173 | ENA
Project description:EMG produced TPA metagenomics assembly of PRJNA813023 data set (gut metagenome).