Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Second draft genome from Spain of the Monkeypox virus 2022 outbreak

ABSTRACT: Second draft genome from Spain of the Monkeypox virus 2022 outbreak

PROVIDER: PRJEB53330 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Monkeypox Outbreak 2022 Spain ISCIII

Project description:Monkeypox Outbreak 2022 Spain ISCIII

| PRJEB53450 | ENA

Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids

Project description:The outbreak-causing monkeypox virus of 2022 (2022 MPXV) is classified as a clade IIb strain and phylogenetically distinct from prior endemic MPXV strains (clades I or IIa), suggesting that its virological properties may also differ. Here, we used human keratinocytes and induced pluripotent stem cell-derived colon organoids to examine the efficiency of viral growth in these cells and the MPXV infection-mediated host responses. MPXV replication was much more productive in keratinocytes than in colon organoids. We observed that MPXV infections, regardless of strain, caused cellular dysfunction and mitochondrial damage in keratinocytes. Notably, a significant increase in the expression of hypoxia-related genes was observed specifically in 2022 MPXV-infected keratinocytes. Our comparison of virological features between 2022 MPXV and prior endemic MPXV strains revealed signaling pathways potentially involved with the cellular damages caused by MPXV infections and highlights host vulnerabilities that could be utilized as protective therapeutic strategies against human mpox in the future.

2023-06-06 | GSE219036 | GEO

Monkeypox Outbreak Sweden 2022

Project description:monkeypox viruses sequenced in Sweden 2022

| PRJEB53129 | ENA

Molecular and phylogenetic characterization of the monkeypox outbreak in Andalusia, Spain

Project description:Molecular and phylogenetic characterization of the monkeypox outbreak in Andalusia, Spain

| PRJEB55075 | ENA

Polyvalent mRNA vaccination elicited potent immune response to monkeypox surface antigens

Project description:The soaring global monkeypox cases lead to a surge in demand for monkeypox vaccine, which far exceeds the supply. mRNA vaccine has achieved great success in prevention of coronavirus disease and holds promise against diverse pathogens. In this study, we generate a polyvalent lipid nanoparticle (LNP) mRNA vaccine candidate for monkeypox virus (MPXV) and evaluate its immunogenicity in animal models. This polyvalent MPXV mRNA vaccine candidate, MPXVac-097, encodes five 2022 MPXV targets that are important surface antigens. Three-dose (prime-boost-booster) MPXVac-097 vaccination elicits strong antibody response to A35R and E8L antigens, moderate response to M1R, but not B6R or A29, highlighting the differences in immunogenicity. Bulk T cell receptor (TCR) sequencing reveals preferential usage of VJ combinations and clonal expansion of peripheral T cells after MPXVac-097 vaccination. These data demonstrate initial feasibility of developing MPXV mRNA vaccine and pave the way for its future optimization.

2023-02-13 | GSE225183 | GEO

Project description:Second draft genome from Spain of the Monkeypox virus 2022 outbreak

| PRJNA844567 | ENA

Monkeypox virus strain:hMpxV/Egypt/MOH-NRC-0002/2022

Project description:Monkeypox virus strain:hMpxV/Egypt/MOH-NRC-0002/2022 Genome sequencing

| PRJNA887588 | ENA

Monkeypox Virus Evolution before 2022 Outbreak.

Project description:Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3) deaminase editing. This microevolutionary pattern most likely reflects community spread of the virus and adaptation to humans.

| S-EPMC9881786 | biostudies-literature

Monkeypox virus infections in children in Spain during the first months of the 2022 outbreak.

Project description: Not available

| S-EPMC9555952 | biostudies-literature

Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids

Project description:Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids

| PRJNA906618 | ENA