Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Monkeypox Outbreak 2022 Spain ISCIII

ABSTRACT: Monkeypox Outbreak 2022 Spain ISCIII

PROVIDER: PRJEB53450 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
		Other
	ERR10297606_1.fastq.gz	Fastqsanger.gz
	ERR10297606_2.fastq.gz	Fastqsanger.gz
	ERR10297607_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 98

Similar Datasets

Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids

Project description:The outbreak-causing monkeypox virus of 2022 (2022 MPXV) is classified as a clade IIb strain and phylogenetically distinct from prior endemic MPXV strains (clades I or IIa), suggesting that its virological properties may also differ. Here, we used human keratinocytes and induced pluripotent stem cell-derived colon organoids to examine the efficiency of viral growth in these cells and the MPXV infection-mediated host responses. MPXV replication was much more productive in keratinocytes than in colon organoids. We observed that MPXV infections, regardless of strain, caused cellular dysfunction and mitochondrial damage in keratinocytes. Notably, a significant increase in the expression of hypoxia-related genes was observed specifically in 2022 MPXV-infected keratinocytes. Our comparison of virological features between 2022 MPXV and prior endemic MPXV strains revealed signaling pathways potentially involved with the cellular damages caused by MPXV infections and highlights host vulnerabilities that could be utilized as protective therapeutic strategies against human mpox in the future.

2023-06-06 | GSE219036 | GEO

Second draft genome from Spain of the Monkeypox virus 2022 outbreak

Project description:Second draft genome from Spain of the Monkeypox virus 2022 outbreak

| PRJEB53330 | ENA

Monkeypox Outbreak Sweden 2022

Project description:monkeypox viruses sequenced in Sweden 2022

| PRJEB53129 | ENA

Molecular and phylogenetic characterization of the monkeypox outbreak in Andalusia, Spain

Project description:Molecular and phylogenetic characterization of the monkeypox outbreak in Andalusia, Spain

| PRJEB55075 | ENA

Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids

Project description:Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids

| PRJNA906618 | ENA

French outbreak of Salmonella Hadar 2022

Project description:French outbreak of Salmonella Hadar 2022

| PRJEB55596 | ENA

Polyvalent mRNA vaccination elicited potent immune response to monkeypox surface antigens

Project description:The soaring global monkeypox cases lead to a surge in demand for monkeypox vaccine, which far exceeds the supply. mRNA vaccine has achieved great success in prevention of coronavirus disease and holds promise against diverse pathogens. In this study, we generate a polyvalent lipid nanoparticle (LNP) mRNA vaccine candidate for monkeypox virus (MPXV) and evaluate its immunogenicity in animal models. This polyvalent MPXV mRNA vaccine candidate, MPXVac-097, encodes five 2022 MPXV targets that are important surface antigens. Three-dose (prime-boost-booster) MPXVac-097 vaccination elicits strong antibody response to A35R and E8L antigens, moderate response to M1R, but not B6R or A29, highlighting the differences in immunogenicity. Bulk T cell receptor (TCR) sequencing reveals preferential usage of VJ combinations and clonal expansion of peripheral T cells after MPXVac-097 vaccination. These data demonstrate initial feasibility of developing MPXV mRNA vaccine and pave the way for its future optimization.

2023-02-13 | GSE225183 | GEO

undefined

Project description:Monkeypox outbreak 2022 Germany

| PRJEB53029 | ENA

Salmonella serotype Virchow outbreak in France, 2022

Project description:Salmonella serotype Virchow outbreak in France, 2022

| PRJEB59228 | ENA

Monkeypox virus strain:hMpxV/Egypt/MOH-NRC-0002/2022

Project description:Monkeypox virus strain:hMpxV/Egypt/MOH-NRC-0002/2022 Genome sequencing

| PRJNA887588 | ENA