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RNA-seq of CCBE1 KO and WT murine hearts

ABSTRACT: RNA-seq of CCBE1 KO and WT murine hearts

PROVIDER: PRJEB56354 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR10293431_1.fastq.gz	Fastqsanger.gz
	ERR10293431_2.fastq.gz	Fastqsanger.gz
	ERR10293432_1.fastq.gz	Fastqsanger.gz
	ERR10293432_2.fastq.gz	Fastqsanger.gz
	ERR10293433_1.fastq.gz	Fastqsanger.gz

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RNA-seq of CCBE1 KO and WT murine hearts

Project description:CCBE1 is a secreted extracellular matrix protein expressed by epicardial cells but its role during epicardial development was still unknown.Using a Ccbe1 knockout (KO) mouse model, we observed that loss of CCBE1 leads to congenital heart defects including thinner and hyper-trabeculated ventricular myocardium. In addition, Ccbe1 mutant hearts displayed reduced proliferation of cardiomyocyte and epicardial cells. RNA-seq data of CCBE1 KO and WT murine hearts indicated deregulation of genes associated with development and morphogenesis including the epithelial-to-mesenchymal transition.

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