Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomes of aneuploid Candida parapsilosis strains

ABSTRACT: Transcriptomes of aneuploid Candida parapsilosis strains

PROVIDER: PRJEB56872 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transcriptomes of aneuploid Candida parapsilosis strains

Project description:In Candida parapsilosis, transcriptomes of two aneuploid adaptors, TJ60 and TJ74, were compared to the euploid parent #12108. Cells were grown in YPD broth at 37C from OD600=0.1 to 1.0. Cells were collected and RNA was extracted.

2023-08-11 | E-MTAB-12322 | biostudies-arrayexpress

Transcriptome analysis of aneuploid and euploid Candida albicans strains

Project description:We obtained ketoconazole tolerant mutants in Candida albicans after exposing the strain SC5314 to inhibitory concentration of ketoconazole. We did RNA-Seq to compare the transcriptomes of the aneuploid strains versus the parent euploid strain.

2020-03-30 | E-MTAB-8671 | biostudies-arrayexpress

Genome instability of aneuploid Candida glabrata strains

Project description:Several aneuploid Candida glabrata strains, each bearing a unique karyotype, were spread on YPD plates. They all exhibited colony size vairations. Randmly 10 large colonies from each strain were sequenced.

2023-06-07 | E-MTAB-12484 | biostudies-arrayexpress

A collection of Candida albicans aneuploid strains

Project description:A collection of Candida albicans aneuploid strains

| PRJEB41161 | ENA

Genome instability of aneuploid Candida glabrata strains

Project description:Genome instability of aneuploid Candida glabrata strains

| PRJEB58794 | ENA

Transcriptome analysis of aneuploid tebuconazole adaptors in Candida albicans

Project description:Candida albicans lab strain SC5314 was used as parent to obtain tebuconazole adaptors. Two adaptors, TJ1503 and TJ1669 were aneuploid. Transcriptomes of these two strains were compared to SC5314.

2023-09-05 | E-MTAB-13210 | biostudies-arrayexpress

Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans

Project description:Abstract: Candida parapsilosis and Candida albicans are human fungal pathogens that belong to the CUG clade in the Saccharomycotina. In contrast to C. albicans, relatively little is known about the virulence properties of C. parapsilosis, a pathogen particularly associated with infections of premature neonates. We describe here the construction of >200 C. parapsilosis strains carrying double allele deletions of transcription factors, protein kinases and species-specific genes. Two independent deletions were constructed for each target gene. Growth in > 40 conditions was tested, including carbon source, temperature, and the presence of antifungal drugs. The phenotypes were compared to C. albicans strains with deletions of orthologous transcription factors. We found that many phenotypes are shared between the two species, such as the role of Upc2 as a regulator of azole resistance. Others are unique. For example, Cph2 plays a role in the hypoxic response in C. parapsilosis and not in C. albicans. We found extensive divergence between the biofilm regulators of the two species. We identified 7 transcription factors and one protein kinase that are required for biofilm development in C. parapsilosis. Only three (Efg1, Bcr1, and Ace2) have similar effects on C. albicans biofilms, whereas Cph2, Czf1, Gzf3 and Ume6 have major roles in C. parapsilosis only. In addition, two transcription factors (Brg1 and Tec1) with well-characterized roles in biofilm formation in C. albicans do not have the same function in C. parapsilosis. We also compared the transcription profile of C. parapsilosis and C. albicans biofilms. Our analysis suggests the processes shared between the two species are predominantly metabolic.

2014-07-21 | GSE57451 | GEO

Expt 6---Comprative transcriptomics of euploid and aneuploid Candida albicans strains

Project description:Candida albicans lab strain SC5314, which is a euploid diploid, was used to generate aneuploid fluconazole adaptors. Transcriptomes of aneuploids were compared to the euploid parent by growing cells in rich YPD broth.

2022-09-26 | E-MTAB-12185 | biostudies-arrayexpress

Candida parapsilosis

Project description:Candida parapsilosis WGS

| PRJNA1068185 | ENA

Role of Hac1 in unfolded protein response in Candida parapsilosis

Project description:Investigation of the role of HAC1 using transcriptional profiling of Candida parapsilosis treated with 5 mM dithiothreitol Gene expression of wild type and hac1 deletion strains were compared during growth in YPD only and growth in YPD with 5 mM DTT

2018-10-08 | GSE120094 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data