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Extra test day for the study: Modulation of Microbial Composition in Ileostomy Patients (INSIDE)

ABSTRACT: Determine the L. rhamnosus CNCM I-3690 survival, adaptation and small bowel microbiome impact in human in response to dietary interventions

PROVIDER: PRJEB61087 | ENA |

REPOSITORIES: ENA

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Gene expression data from C.elegans

Project description:Numerous studies have shown that resistance to oxidative stress is crucial to stay healthy and to reduce the adverse effects of aging. Accordingly, nutritional interventions using antioxidant food-grade compounds or food products are currently an interesting option to help improve health and quality of life in the elderly. Live lactic acid bacteria (LAB) administered in food, such as probiotics, may be good antioxidant candidates. Nevertheless, information about LAB-induced oxidative stress protection is scarce. To identify and characterize new potential antioxidant probiotic strains, we have developed a new functional screening method using the nematode Caenorhabditis elegans as host. C. elegans were fed on different LAB strains (78 in total) and nematode viability was assessed after oxidative stress (3mM and 5mM H2O2). One strain, identified as Lactobacillus rhamnosus CNCM I-3690, protected worms by increasing their viability by 30% and, also, increased average worm lifespan by 20%. We performed a transcriptomic analysis of C. elegans fed with this strain and showed that increased lifespan is correlated with differential expression of the DAF-16/insulin-like pathway, which is highly conserved in humans. Gene expression in C. elegans wild-type strain (N2) was analyzed in worm populations fed with E. coli OP50 (control condition) or the corresponding LAB (Lactobacillus rhamnosus CNCM I-3690 or Lactobacillus rhamnosus CNCM I-4317) . Three days and ten days feeding period was analyzed.

2012-12-31 | E-GEOD-42192 | biostudies-arrayexpress

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [bacterial gene expression]

Project description:Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis remains unknown. Here, we showed that B. wadsworthia synergize with HFD to promote higher inflammation, intestinal barrier dysfunction and bile acid dysmetabolism, leading to higher glucose dysmetabolism and hepatic steatosis. Host-microbiota transcriptomics analysis unraveled pathways, particularly butanoate metabolism, which may underlie the metabolic effects mediated by B. wadsworthia. Pharmacological suppression of B. wadsworthia-associated inflammation unmasked the bacterium’s intrinsic capacity to induce a negative impact on glycemic control and hepatic function. Finally, the probiotic Lactobacillus rhamnosus CNCM I-3690 was able to limit B. wadsworthia-induced immune and metabolic impairment by limiting its expansion, reducing inflammation and reinforcing intestinal barrier. Our results support a new avenue for interventions against western diet-driven inflammatory and metabolic diseases.

2018-05-26 | GSE112387 | GEO

Bilophila wadsworthia worsens high-fat diet-induced metabolic impairments in inflammation dependent and independent manners [mouse gene expression]

2018-05-26 | GSE111451 | GEO

L. rhamnosus CNCM i-4036

Project description:Lactobacillus rhamnosus CNCM i-4036

| PRJEB10111 | ENA

INSIDE survival study

Project description:survival of rhamnosus in the human GI tract

| PRJEB61139 | ENA

Gene expression data from C.elegans

2012-12-31 | GSE42192 | GEO

Lacticaseibacillus rhamnosus strain:CNCM I-4036

Project description:Lacticaseibacillus rhamnosus strain:CNCM I-4036 Genome sequencing

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Project description:Over-production of exopolysaccharide by Lacticaseibacillus rhamnosus CNCM I-3690

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Lacticaseibacillus rhamnosus strain:CNCM-I-3698

Project description:Lacticaseibacillus rhamnosus strain:CNCM-I-3698 Genome sequencing and assembly

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Composition and functional properties of Lacticaseibacillus rhamnosus-derived EVs are dependent on growth phase of bacterial culture

Project description:To describe the impact of growth-phase of microbial culture of L. rhamnosus ATCC53103on the biophysical characterization, proteome and immunomodulatory properties of its MVs.

2024-08-23 | PXD041580 | Pride

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