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Rad50 ChIPseq in Drosophila wandering larval central nervous system and in embryos stage 16

ABSTRACT: Rad50 ChIPseq in Drosophila wandering larval central nervous system and in embryos stage 16

PROVIDER: PRJEB62509 | ENA |

REPOSITORIES: ENA

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Rad50 ChIPseq in Drosophila wandering larval central nervous system and in embryos stage 16

Project description:Rad50 is overexpressed in larval brain compared to embryo and is likely linked to stage specific chromatin modification. To identify the targets of Rad50, ChIPseq with Rad50 antibody was done in duplicate on wandering larval brain and on embryo stage 16.

2024-12-31 | E-MTAB-12982 | biostudies-arrayexpress

RNAseq of RAD50∆5.1 null mutant and WT W1118 larval stage 3 CNS

Project description:This experiments follows up ChIPseq experiments and aims to investigate the role of Rad50 on gene expression in drosophila larval stage 3 CNS.

2023-12-01 | E-MTAB-13490 | biostudies-arrayexpress

Characterisation of TET function in drosophila larval central nervous system

Project description:Enzymes of the Ten Eleven Translocation (TET) family play a key role in the regulation of gene expression in many species by oxidizing 5-methylcytosine (5mC), a prominent epigenetic mark, into 5-hydroxymethylcytosine (5hmC). Yet, TET proteins also have non-canonical modes of action beyond 5mC oxidation, notably in Drosophila, whose genomes is devoid of 5mC. Here, we used a combination of NGS analyses to studied the funciton and mode of action of Tet in the central nervous system of Drosophila larvae.

2024-04-02 | GSE250415 | GEO

Analysis of gene expression in the Drosophila larval central nervous system

Project description:Recent studies have brought contrasting results concerning 6-methyl-adenosine (6mA) as an epigenetic mark in eukaryote genomes. Here we investigated the genomic characteristics of 6mA in drosophila larval central nervous system in wild type and tet mutant contexts using PacBio SMRT-seq. In parallel, we performed RNA-seq experiments to assess gene expression in these two conditions.

2023-12-01 | GSE206852 | GEO

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Project description:RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody 3F8, can find tumor cells and carry tumor-killing substances to them without harming normal cells. This may be an effective treatment for central nervous system cancer or leptomeningeal metastases. PURPOSE: This phase II trial is studying the side effects and how well iodine I 131 monoclonal antibody 3F8 works in treating patients with central nervous system cancer or leptomeningeal cancer.

| 2037925 | ecrin-mdr-crc

Characterisation of TET function in drosophila larval central nervous system

Project description:Characterisation of TET function in drosophila larval central nervous system

| PRJNA1054017 | ENA

Analysis of gene expression in the Drosophila larval central nervous system

Project description:Analysis of gene expression in the Drosophila larval central nervous system

| PRJNA852437 | ENA

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts

Project description:Rad50 is a component of the conserved MRE11-RAD50-NBS1 (MRN) complex, which functions in genome stability and the cell’s ability to deal with stalled DNA replication forks. We identified Rad50 as a factor important for R-loop tolerance and thus mapped DNA:RNA hybrids in Rad50KO cells and compare them to previously reported wild-type and Sgs1KO profiles.

2019-10-31 | E-MTAB-7885 | biostudies-arrayexpress

Efavirenz Central Nervous System Side Effects

Project description:Efavirenz Central Nervous System Side Effects

| PRJNA354669 | ENA

chipseq

Project description:chipseq data

| PRJEB39779 | ENA