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Diet CD4+ response

ABSTRACT: Synchronized response of CD4+ T cells to short-term dietary changes leads to windows of mucosal and systemic immune depression

PROVIDER: PRJEB62783 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR11511000_1.fastq.gz	Fastqsanger.gz
	ERR11511000_2.fastq.gz	Fastqsanger.gz
	ERR11511001_1.fastq.gz	Fastqsanger.gz
	ERR11511001_2.fastq.gz	Fastqsanger.gz
	ERR11511002_1.fastq.gz	Fastqsanger.gz

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Synchronized response of CD4+ T cells to short-term dietary changes - Tissue RNA sequencing diet change

Project description:Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich in fat over plant-based diets, especially for short periods of time. The health consequences of this short-term consumption of energy-dense nutrients remain still unclear. We found that every short-term, reiterated switches to feast diets mimicking our social eating behavior, breached the potential buffering effect of the intestinal microbiota and deeply reorganized the immunological architecture of mucosa-associated lymphoid tissues. The first dietary switch was sufficient to induce transient mucosal immune depression and suppress systemic, antigen-specific immunity leading to higher susceptibility to Salmonella Typhimurium and Listeria monocytogenes infections. This was explained by a reduction of CD4+ T cell metabolic fitness and cytokine production due to impaired mTOR activity in response to withdrawal of microbial provision of fiber metabolites. Reintroducing dietary fiber efficiently rewired T cell metabolism and restored both mucosal and systemic CD4+ T cell functions and immunity. Finally, dietary intervention study in human volunteers confirmed the impact of short-term dietary switches on human CD4+ T cell functionality. This work reveals that short-term nutritional changes cause a drastic yet transient depression of both mucosal and systemic immunity, creating windows of opportunities for pathogenic infections.

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