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MRNA-Seq of Danio rerio exposed to different concentrations of the fungicide difenoconazole against untreated control groups

ABSTRACT: mRNA-Seq of Danio rerio exposed to different concentrations of the fungicide difenoconazole against untreated control groups

PROVIDER: PRJEB65329 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR11872216.fastq.gz	Fastqsanger.gz
	ERR11872217.fastq.gz	Fastqsanger.gz
	ERR11872218.fastq.gz	Fastqsanger.gz
	ERR11872219.fastq.gz	Fastqsanger.gz
	ERR11872220.fastq.gz	Fastqsanger.gz

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Quantitative profiling of proteome extracted from zebrafish embryos exposed to different concentrations of the fungicide difenoconazole against untreated control groups.

Project description:In the present study OMICs analysis was employed to investigate the early molecular responses of zebrafish embryos to exposure to the fungicide difenoconazole. Difenoconazole, a sterol biosynthesis inhibitor according to Fungicide Resistance Action Committee (FRAC) classification, may also induce adverse effects on non-target organisms inhabiting the environment. Early molecular responses in terms of transcriptome and proteome analysis were investigated and refined to select potentially substance specific biomarker candidates for early prediction of difenoconazole toxicity in zebrafish embryos.

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mRNA-Seq of Danio rerio exposed to different concentrations of the fungicide difenoconazole against untreated control groups

Project description:In the present study transcriptome analysis was employed to investigate the early molecular responses to exposure to the fungicide difenoconazole, a sterol biosynthesis inhibitor according to Fungicide Resistance Action Committee (FRAC) classification. Zebrafish embryos were exposed to difenoconazole according to OECD guidelines (OECD test No. 236). At the end of exposure time (96 hours), simultaneous RNA and protein extraction from 10 embryos was performed using a Macherey & Nagel RNA/protein extraction kit. The obtained RNA extracts were sequenced using Illumina HiSeq 4000 System and the obtained sequences went through bioinformatic analysis pipeline to Identify and count the detected gene sequences followed by differential gene expression analysis. Finally, potential substance specific biomarker candidates were refined and selected based on the differential expression patterns and the biological functions investigation of the detected DEGs.

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mRNA-Seq of Danio rerio exposed to different concentrations of the fungicide metalaxyl against untreated control groups

Project description:mRNA-Seq of Danio rerio exposed to different concentrations of the fungicide metalaxyl against untreated control groups

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Project description:Exposure of a resistance and sensitive isolate of Penicillium to difenoconazole fungicide and acetone as a control for 24 hours.

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Project description:Chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) is a broad spectrum fungicide used extensively in agricultural crops . The aim of this study is to analyse the effects of Chorothalonil on the gene expression profiles in zebrafish (Danio rerio), exposed to two concentrations of the fungicide in the water. Nominal concentrations were 1) Low 0.007mg/l (environmentally relevent) and 2) High 0.035mg/ml . A commercial third generation microarray for Danio rerio (Agielnt V3, 4x44k) was used to identify patterns of gene expression in male livers during a 96h toxicological assay.

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