Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of Gut Microbiota Profile Associated with Colorectal Cancer in Saudi Population

ABSTRACT: In Saudi Arabia, those who have been diagnosed with CRC at a late stage were included in this study to investigate the gut microbial profile and its association to diet. This study also examines the risk factors for CRC in Saudi Arabia, focusing on diet quality, consumption of fruits and vegetables, and fat intake (total fat, saturated fat, monounsaturated fat, polyunsaturated fat, fat from plant food sources, and fat from animal sources). It also examines the role of dysbiosis in the gut microbiota and its potential link to the development of CRC.

PROVIDER: PRJEB65611 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Identification of a transcriptomic signature of X chromosome overdosage in Saudi Klinefelter syndrome iPSCs.

Project description:Klinefelter syndrome (KS) is the most prevalent aneuploidy in males and is characterized by an extra copy of the X chromosome,while the non-mosaic form of KS with 47,XXY karyotype is the most frequent (80-90%), less common non-disjunction events during the early mitotic division of the zygote result in mosaic forms of KS (47,XXY/46,XY). Here, using a paradigmatic cohort of KS-inducible pluripotent stem cells (iPSCs) carrying 47,XXY karyotypes we present the first iPSC-based disease-modeling study performed on KS patients from Saudi Arabia. We profiled the transcriptome of these Saudi KS-iPSCs, virtually characterized by subduedcgenetic backgrounds. Moreover, we performed a comparative transcriptomic analysis to assess the aberrant gene expression profile due to X dosage imbalance in four Saudi and five European and North American 47,XXY patients-derived iPSCs from our previously published study on KS and high-grade sex chromosome aneuploidies (SCAs). We identified a transcriptomic signature including ten PAR1 genes and thirteen non-PAR escape genes consistently upregulated in KS compared to 46,XY controls in both groups, as well as 193 consistenty disregulated autosomal genes. Our results indicate that the global transcriptional impact of X chromosome overdosage in KS is largely attributable to X-linked genes escaping X inactivation, regardless of the geographical area of origin, ethnicity, and genetic background.

2023-08-02 | GSE220268 | GEO

whole genome sequencing of Staphylococcus aureus from Saudi Arabia

Project description:MRSA genomic epidemiology in Saudi Arabia

| PRJEB59751 | ENA

Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia

Project description:Whole transcript expression was profiled using the Affymetrix 1.0 array in human bronchial epithelial cells exposed to PM collected from Saudi Arabia for 1 or 4 days. The differentially expressed genes were identified and analyzed for enriched networks and pathways using Ingenuity Pathway Analysis (IPA). We have identified 140 and 230 genes that significantly changed more than 1.5 fold after PM exposure for 1 or 4 days, respectively. IPA analysis revealed that different exposure durations triggered distinct pathways. Genes involved in NRF2-mediated response to oxidative stress were up-regulated after 1 day exposure. In contrast, cells exposed for 4 days exhibited significantly changes in genes related to cholesterol and lipid synthesis pathways.

2012-08-01 | GSE38172 | GEO

Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia

2012-07-31 | E-GEOD-38172 | biostudies-arrayexpress

Safety and Effectiveness Study of Remsima in the Treatment of Inflammatory Bowel Diseases Among Saudi Arabia Patients

Project description:The purpose of this observational study is to assess the safety and effectiveness of biosimilar Infliximab in patients with inflammatory bowel disease (IBD) in Saudi Arabia where no visits or intervention(s) additional to the daily practice will be performed.

| 2267353 | ecrin-mdr-crc

Saudi desert soil Microbiome

Project description:The microbiome of four soil samples from arid and semi-arid region of Saudi Arabia.

| PRJEB33715 | ENA

MDR UPEC in Saudi Arabia

Project description:Genomic characterization of Multi-Drug Resistant Uropathogenic Escherichia coli isolates from Riyadh, Saudi Arabia

| PRJEB17503 | ENA

Saudi Schizophrenia

Project description:CNV Screening of Saudi Schizophrenia

| PRJEB57402 | ENA

The Etiological Bases of Giftedness: Epidemiological study of cognitive ability in children in Saudi Arabia

Project description:The Etiological Bases of Giftedness: Epidemiological study of cognitive ability in children in Saudi Arabia