Project description:Gut dysbiosis is closely involved in the pathogenesis of inflammatory bowel disease (IBD). However, it remains unclear whether IBD-associated gut dysbiosis plays a primary role in disease manifestation or is merely secondary to intestinal inflammation. Here, we established a humanized gnotobiotic (hGB) mouse system to assess the functional role of gut dysbiosis associated with two types of IBD - Crohn's disease (CD) and ulcerative colitis (UC). In order to explore the functional impact of dysbiotic microbiota in IBD patients on host immune responses, we analyzed gene expression profiles in colonic mucosa of hGB mice colonized with healty (HC), CD, and UC microbiota.

2015-10-10 | GSE73882 | GEO

IRON-IBD

Project description:Effects of different iron replacement methods to gut microbiome of IBD and non IBD patients

| PRJEB48168 | ENA

The vegetable virome and its contribution to the human gut virome

Project description:The food–gut axis: the phyllosphere virome of fresh vegetables is diverse, abundant, and transmitted to the human gut virome

| PRJEB79316 | ENA

Genome-wide maps of chromatin state in immune cells derived from IBD patients

Project description:We generated genome-wide chromatin-state maps of immune cells purified from LPMC of IBD and non-IBD patients by using next generation sequencing.

2019-12-27 | GSE67273 | GEO

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