Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comprehensive Analysis of Hematopoietic Stem Cell Niche

ABSTRACT: Comprehensive Analysis of Hematopoietic Stem Cell Niche

PROVIDER: PRJEB7266 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR599385_1.fastq.gz	Fastqsanger.gz
	ERR599385_2.fastq.gz	Fastqsanger.gz
	ERR599386_1.fastq.gz	Fastqsanger.gz
	ERR599386_2.fastq.gz	Fastqsanger.gz
	ERR599387_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 26

Similar Datasets

Molecular analysis of the subaortic hematopoietic stem cell niche

Project description:Molecular analysis of the subaortic hematopoietic stem cell niche

| PRJNA669831 | ENA

Molecular analysis of the subaortic hematopoietic stem cell niche [E10.5_1]

Project description:Molecular analysis of the subaortic hematopoietic stem cell niche [E10.5_1]

| PRJNA670012 | ENA

Molecular analysis of the subaortic hematopoietic stem cell niche [E12.5]

Project description:Molecular analysis of the subaortic hematopoietic stem cell niche [E12.5]

| PRJNA670008 | ENA

Molecular analysis of the subaortic hematopoietic stem cell niche [E11.5]

Project description:Molecular analysis of the subaortic hematopoietic stem cell niche [E11.5]

| PRJNA670009 | ENA

Molecular analysis of the subaortic hematopoietic stem cell niche [E10.5_2]

Project description:Molecular analysis of the subaortic hematopoietic stem cell niche [E10.5_2]

| PRJNA670010 | ENA

A Novel Osteoclastic Network Determines Niche for Mouse Hematopoietic Stem Cells In Vitro

Project description:The importance of extrinsic regulation of hematopoietic stem cell activity is increasingly acknowledged. Here we report the generation of a new niche system, which supports expansion of mouse hematopoietic stem cells in vitro. Characterization of this niche revealed a transcriptional regulatory network including four critical factors, namely FOS, SPI1, KLF10 and TFEC. Interestingly, these factors are essential for osteoclastogenesis, thus revealing an osteoclastic network that supports hematopoietic stem cell self-renewal. Lentiviral vectors containing putative transcription factors regulating HSC expansion were transfected into GPE cells and gene expression values were compared to empty vector controls.

2013-12-31 | E-GEOD-39835 | biostudies-arrayexpress

Cardiovascular disease perturbs the vascular hematopoietic stem cell niche

Project description:Cardiovascular disease perturbs the vascular hematopoietic stem cell niche

| PRJNA603792 | ENA

Bmi1 suppresses adipogenesis in the hematopoietic stem cell niche

Project description:Bmi1 suppresses adipogenesis in the hematopoietic stem cell niche

| PRJNA496529 | ENA

Identification of a portal vessel-associated fetal liver hematopoietic stem cell niche

Project description:Whereas the cellular basis of the hematopoietic stem cell (HSC) niche in the bone marrow has been characterized, the nature of the fetal liver (FL) niche is not yet elucidated. We show that Nestin+NG2+ pericytes associate with portal vessels, forming a niche promoting HSC expansion. Nestin+NG2+ cells and HSCs scale during development with the fractal branching patterns of portal vessels, tributaries of the umbilical vein. After closure of the umbilical inlet at birth, portal vessels undergo a transition from Neuropilin-1+Ephrin-B2+ artery to EphB4+ vein phenotype, associated with a loss of peri-portal Nestin+NG2+ cells and emigration of HSCs away from portal vessels. These data support a model in which HSCs are titrated against a peri-portal vascular niche with a fractal-like organization enabled by placental circulation. Characterization of the transcriptome of fetal liver and adult bone marrow niche using RNA-seq

2015-12-03 | E-GEOD-72341 | biostudies-arrayexpress

A Novel Osteoclastic Network Determines Niche for Mouse Hematopoietic Stem Cells In Vitro

2013-12-31 | GSE39835 | GEO