Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq analysis of POLDIP2 mutant in Drosophila melanogaster

ABSTRACT: RNA-seq analysis of POLDIP2 mutant in Drosophila melanogaster

PROVIDER: PRJEB75956 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR13148464_1.fastq.gz	Fastqsanger.gz
	ERR13148464_2.fastq.gz	Fastqsanger.gz
	ERR13148465_1.fastq.gz	Fastqsanger.gz
	ERR13148465_2.fastq.gz	Fastqsanger.gz
	ERR13148466_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

RNA-seq analysis of POLDIP2 mutant in Drosophila melanogaster

Project description:Maternal inheritance of mitochondrial DNA (mtDNA) is highly conserved in metazoans. While many species eliminate paternal mtDNA during late sperm development to foster maternal inheritance, the regulatory mechanisms governing this process remain elusive. Through a large-scale genetic screen in Drosophila, we identified 47 mutant lines exhibiting substantial retention of mtDNA in mature sperm. We mapped one line to Poldip2, a gene predominantly expressed in the testis. Disruption of Poldip2 led to pronounced mtDNA retention in mature sperm and subsequent paternal transmission to progeny. Further investigation via imaging, biochemical analyses and ChIP assays revealed that POLDIP2 is a mitochondrial matrix protein capable of binding to mtDNA. Moreover, we uncovered that CLPX, a key component of the major mitochondrial protease, binds to POLDIP2 to co-regulate mtDNA elimination in Drosophila spermatids. This study shed light on the mechanisms underlying mtDNA removal during spermatogenesis, underscoring the pivotal role of this process in safeguarding maternal inheritance.

2024-06-10 | E-MTAB-14104 | biostudies-arrayexpress

POLDIP2 is required for mtDNA elimination during spermatogenesis to ensure maternal inheritance in Drosophila melanogaster

2024-06-04 | E-MTAB-14100 | biostudies-arrayexpress

CG7358 mutant Drosophila melanogaster sequencing

Project description:CG7358 mutant Drosophila melanogaster sequencing

| PRJNA432658 | ENA

RNA-Seq of head tissue from Drosophila melanogaster Wild Type and AdarEA mutant

Project description:We profiled gene expression in flies with and without A-to-I RNA editing (AdarEA mutant Drosophila melanogaster with a Canton-S background).

2017-01-04 | GSE86054 | GEO

RNA-Seq of head tissue from Drosophila melanogaster Wild Type and Adar5G1 mutant

Project description:We profiled gene expression in flies with and without A-to-I RNA editing (AdarEA mutant Drosophila melanogaster with a Canton-S background).

2019-03-15 | GSE128332 | GEO

Gene expression profiling of adult Drosophila melanogaster prickle-prickle mutant brains

Project description:Study of genome-wide differential gene expression of adult Drosophila melanogaster prickle-prickle mutant brains compared to control animals.

2023-07-10 | GSE155565 | GEO

Cut&Run in Drosophila melanogaster control, mutant and knockdown ovaries

Project description:H3K27me3 profiles using Cleavage under targets and Release using nuclease (Cut&Run) in control and KD Drosophila melanogaster ovaries. We examined the impact on chromatin profiles in Drosophila melanogaster ovaries in which the lid, the Sin3a, the Snr1 or the mod(mdg4) gene have been selectively knocked down by tissue-specific shRNA expression. We additionally explored H3K27me3 and H3K9me3 in control and dhd mutant ovaries either carrying or not a transgene.

2021-12-10 | GSE174250 | GEO

Deep peptidomics analysis of Drosophila melanogaster

Project description:A deep peptidomics workflow was used to identify alternative proteins in Drosophila melanogaster samples.

2022-01-07 | MSV000088656 | MassIVE

Gene expression profiling of adult Drosophila melanogaster prickle-spiny legs mutant brains

Project description:Study of genome-wide differential gene expression of adult Drosophila melanogaster prickle-spiny legs mutant brains compared to control animals.

2023-03-01 | GSE154686 | GEO

CG7358 mutant Drosophila melanogaster sequencing

Project description:To understand the function of gene CG7358 in Drosophila melanogaster, including indentification of those genes whose expression levels or alternative splicing are affected by CG7358.

2018-04-18 | GSE110047 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data