Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gut decolonization of multidrug-resistant Escherichia coli

ABSTRACT: Gut decolonization of multidrug-resistant Escherichia coli clinical isolates via cooperative niche exclusion

PROVIDER: PRJEB76066 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR13187000_1.fastq.gz	Fastqsanger.gz
	ERR13187000_2.fastq.gz	Fastqsanger.gz
	ERR13187100_1.fastq.gz	Fastqsanger.gz
	ERR13187100_2.fastq.gz	Fastqsanger.gz
	ERR13187200_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 1598

Similar Datasets

multidrug-resistant Pasteurellaceae

Project description:Analysis of multidrug-resistant Mannheimia haemolytica and Pasteurella multocida isolates

| PRJNA774931 | ENA

Multidrug-resistant Enterococcus faecium

Project description:Multidrug-resistant Enterococcus faecium

| PRJEB64614 | ENA

Interplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans

Project description:Cryptococcus neoformans poses a great threat to human communities, given that it quickly becomes resistant to available antifungal drugs. Herein, a conserved chromatin remodeler, Isw1, is shown to function as a master transcriptional modulator of genes responsible for multidrug resistance. It reciprocally controls drug resistance, and cells with disrupted ISW1 demonstrate profound resistance to fluconazole, ketoconazole, 5-fluorocytosine and 5-fluorouracil. Mass spectrometry reveals that Isw1 is both acetylated and ubiquitinated. These two protein posttranslational modifications confer an interplay regulation mechanism that controls Isw1 protein degradation via a ubiquitin-mediated proteasome and, consequently, C. neoformans resistance to drugs. Functional mutagenesis analysis of acetylation and ubiquitination sites reveals that the acetylation status of the lysine 97 residue on Isw1 coordinates its ubiquitination processes at lysines 113 and 441 by modulating the protein interactions between Isw1 and Cdc4, an E3 ligase. Clinical C. neoformans isolates overexpressing the undegradable ISW1 mutant demonstrate impaired drug-resistant phenotypes. Collectively, our studies reveal a sophisticated acetylation-Isw1-ubiquintation regulation axis that controls multidrug resistance in fungal pathogens.

2023-06-20 | GSE235148 | GEO

Interplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans

2022-11-10 | GSE217187 | GEO

Multidrug resistant Enterobacteriaceae

Project description:Multidrug resistant Enterobacteriaceae isolated from carriage and infection in hospitalised individuals

| PRJNA286707 | ENA

Transcription profiling by array of Salmonella typhimurium SL1344 derived multidrug resistant mutant

Project description:Transcriptome of a ciprofloxacin selected multidrug resistant mutant derived from Salmonella Typhimurium SL1344

2010-12-04 | E-MEXP-2696 | biostudies-arrayexpress

Multidrug Resistant Shigella flexneri

Project description:Investigation of the origins of multidrug resistant Shigella flexneri in a patient

| PRJEB39384 | ENA

Comprehensive Proteomic Analysis Reveals Novel Antibiotic Resistance Proteins and Biomarkers in Multidrug-Resistant in Klebsiella pneumoniae Clinical Isolates

Project description:The emergence of multidrug-resistant (MDR) Klebsiella pneumoniae represents a major public health concern, primarily driven by its ability to evade a wide range of antibiotics. Despite extensive genomic studies, proteomic insights into antibiotic resistance mechanisms remain scarce. Here, we employed a data-independent acquisition (DIA)-based quantitative proteomics approach to investigate proteomic differences between 87 MDR and 20 antibiotic-sensitive K. pneumoniae clinical isolates. A total of 3,380 proteins were identified, with 896 showing significant differential expression. MDR isolates exhibited increased expression of efflux pumps, beta-lactamases, and transcriptional regulators, while proteins associated with glycerolipid metabolism and transport were enriched in sensitive strains. To validate our findings, an independent cohort of 10 MDR and 11 sensitive isolates was analyzed. Key biomarkers identified in the discovery cohort, including pyruvate decarboxylase and aldehyde dehydrogenase, were validated with high discriminatory power (AUC > 0.85) in the validation cohort. These findings provide novel insights into the molecular mechanisms of antibiotic resistance and identify promising biomarkers for diagnosing MDR K. pneumoniae, offering potential avenues for therapeutic intervention.

2024-10-14 | PXD056798 |

Multidrug-resistant bacteria isolated from water

Project description:Multidrug-resistant bacteria isolated from water

| PRJEB29745 | ENA

Colistin dependence in multidrug-resistant Acinetobacter baumannii

Project description:Here we investigated colistin effects on A. baumannii, employing a Mass spectrometry approach and comparing a colistin-susceptible multidrug-resistantclinical isolate to its colistin-dependent subpopulation obtained by subsequent passages in moderate colistin concentrations. Colistin dependence might represent a stepping-stone to resistance, but the mechanisms of colistin dependence are far from clear.

2021-01-12 | PXD020218 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data