Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of Salmonella typhimurium SL1344 derived multidrug resistant mutant

ABSTRACT: Transcriptome of a ciprofloxacin selected multidrug resistant mutant derived from Salmonella Typhimurium SL1344

ORGANISM(S): Salmonella typhimurium

SUBMITTER: Vito Ricci 

PROVIDER: E-MEXP-2696 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The TCA cycle is not required for selection or survival of multidrug-resistant Salmonella.

Ricci Vito V   Loman Nick N   Pallen Mark M   Ivens Alasdair A   Fookes Maria M   Langridge Gemma C GC   Wain John J   Piddock Laura J V LJ  

The Journal of antimicrobial chemotherapy 20111220 3

<h4>Objectives</h4>The initial aim of this study was to use a systems biology approach to analyse a ciprofloxacin-selected multidrug-resistant (MDR) Salmonella enterica serotype Typhimurium, L664.<h4>Methods</h4>The whole genome sequence and transcriptome of L664 were analysed. Site-directed mutagenesis to recreate each mutation was carried out, followed by phenotypic characterization and mutation frequency analysis. As a mutation in the TCA cycle was detected we tested the controversial hypothe  ...[more]

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