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Sampling frequency matters: mapping of the healthy infants' gut microbiome during the first year of life - part B

ABSTRACT: Mapping the Healthy Infant Gut Microbiome Over the First Year

PROVIDER: PRJEB82127 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR13929200_1.fastq.gz	Fastqsanger.gz
	ERR13929200_2.fastq.gz	Fastqsanger.gz
	ERR13929300_1.fastq.gz	Fastqsanger.gz
	ERR13929300_2.fastq.gz	Fastqsanger.gz
	ERR13929400_1.fastq.gz	Fastqsanger.gz

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Sampling frequency matters: mapping of the healthy infants' gut microbiome during the first year of life - part A

Project description:Mapping the Healthy Infant Gut Microbiome Over the First Year

| PRJEB82126 | ENA

Transcription profling of infants (<1 year of age) diagnosed with Acute Lymphoblastic Leukemia (ALL) characterised by genomic translocation.

Project description:Acute Lymphoblastic Leukemia (ALL) in infants (<1 year) is characterized by a poor prognosis and a high incidence of MLL translocations. Several studies demonstrated the unique gene expression profile associated with MLL-rearranged ALL, but generally small cohorts were analyzed as uniform patient groups regardless of the type of MLL translocation, while the analysis of translocation-negative infant ALL remained unacknowledged. We generated and analyzed primary infant ALL expression profiles (n=73) typified by translocations t(4;11), t(11;19) and t(9;11), or the absence of MLL translocations, in order to study translocation-specific gene expression between the different genetic subtypes of infant ALL.

2009-12-15 | E-GEOD-19475 | biostudies-arrayexpress

Gene expression data from infants (<1 year of age) diagnosed with Acute Lymphoblastic Leukemia (ALL)

2009-12-16 | GSE19475 | GEO

Diurnal rhythmicity of fecal microbiota and metabolite profiles in the first year of life

Project description:Microbiota assembly in the infant gut is influenced by time and duration of dietary exposure to breast-milk, infant formula and solid foods.

2023-10-18 | MSV000093140 | MassIVE

Diurnal rhythmicity of fecal microbiota and metabolite profiles in the first year of life: a randomized controlled interventional trial with infant formula

Project description:Microbiota assembly in the infant gut is influenced by time and duration of dietary exposure to breast-milk, infant formula and solid foods. In this randomized controlled intervention study, longitudinal sampling of infant stools (n=998) showed similar development of fecal bacterial communities between formula- and breast-fed infants during the first year of life (N=210). Infant formula supplemented with galacto-oligosaccharides (GOS) was most efficient to sustain high levels of bifidobacteria compared to formula containing B. longum and B. breve or placebo. Metabolite (untargeted) and bacterial profiling (16S rRNA/shallow metagenomics sequencing) revealed 24-hour oscillations and integrated data analysis identified circadian networks. Rhythmicity in bacterial diversity, specific taxa and functional pathways increased with age and was most pronounced following breast-feeding and GOS-supplementation. Circadian rhythms in dominant taxa were discovered ex-vivo in a chemostat model. Hence microbiota rhythmicity develops early in life, likely due to bacterial intrinsic clock mechanism and is affected by diet.

2024-01-10 | MSV000093802 | MassIVE

Single-cell RNA-sequencing of mouse thymic epithelial cells across the first year of life

Project description:The thymus shapes the T cell receptor repertoire, and is one of the first organs to rapidly age, with gross changes in cellularity and architecture. To resolve the nature of these changes we used SMART-Seq2 on FACS purified thymic epithelial cells (TEC) across the first year of mouse life. We sorted 4 TEC populations in each of 5 mice at each age (1 week, 4 weeks, 16 weeks, 32 weeks and 52 weeks old).

2020-09-14 | E-MTAB-8560 | biostudies-arrayexpress

Genome-Wide Association Studies of Diarrhea Frequency and Duration in the First Year of Life in Bangladeshi Infants.

Project description:BackgroundDiarrhea is the second leading cause of death in children under 5 years old worldwide. Known diarrhea risk factors include sanitation, water sources, and pathogens but do not fully explain the heterogeneity in frequency and duration of diarrhea in young children. We evaluated the role of host genetics in diarrhea.MethodsUsing 3 well-characterized birth cohorts from an impoverished area of Dhaka, Bangladesh, we compared infants with no diarrhea in the first year of life to those with an abundance, measured by either frequency or duration. We performed a genome-wide association analysis for each cohort under an additive model and then meta-analyzed across the studies.ResultsFor diarrhea frequency, we identified 2 genome-wide significant loci associated with not having any diarrhea, on chromosome 21 within the noncoding RNA AP000959 (C allele odds ratio [OR] = 0.31, P = 4.01 × 10-8), and on chromosome 8 within SAMD12 (T allele OR = 0.35, P = 4.74 × 10-7). For duration of diarrhea, we identified 2 loci associated with no diarrhea, including the same locus on chromosome 21 (C allele OR = 0.31, P = 1.59 × 10-8) and another locus on chromosome 17 near WSCD1 (C allele OR = 0.35, P = 1.09 × 10-7).ConclusionsThese loci are in or near genes involved in enteric nervous system development and intestinal inflammation and may be potential targets for diarrhea therapeutics.

| S-EPMC11007397 | biostudies-literature

GNPS - Diurnal rhythmicity of fecal microbiota and metabolite profiles in the first year of life

Project description:Microbiota assembly in the infant gut is influenced by time and duration of dietary exposure to breast-milk, infant formula and solid foods.

2023-10-18 | MSV000093140 | GNPS

Iron stores of breastfed infants during the first year of life.

Project description:The birth iron endowment provides iron for growth in the first months of life. We describe the iron endowment under conditions of low dietary iron supply. Subjects were infants participating in a trial of Vitamin D supplementation from 1 to 9 months. Infants were exclusively breastfed at enrollment but could receive complementary foods from 4 months but not formula. Plasma ferritin (PF) and transferrin receptor (TfR) were determined at 1, 2, 4, 5.5, 7.5, 9 and 12 months. At 1 month PF ranged from 38 to 752 µg/L and was only weakly related to maternal PF. PF declined subsequently and flattened out at 5.5 months. PF of females was significantly higher than PF of males except at 12 months. TfR increased with age and was inversely correlated with PF. PF and TfR tracked strongly until 9 months. Iron deficiency (PF < 10 µg/L) began to appear at 4 months and increased in frequency until 9 months. Infants with ID were born with low iron endowment. We concluded that the birth iron endowment is highly variable in size and a small endowment places infants at risk of iron deficiency before 6 months. Boys have smaller iron endowments and are at greater risk of iron deficiency than girls.

| S-EPMC4042569 | biostudies-literature

Do Infants in the First Year of Life Expect Equal Resource Allocations?

Project description:Recent research has provided converging evidence, using multiple tasks, of sensitivity to fairness in the second year of life. In contrast, findings in the first year have been mixed, leaving it unclear whether young infants possess an expectation of fairness. The present research examined the possibility that young infants might expect windfall resources to be divided equally between similar recipients, but might demonstrate this expectation only under very simple conditions. In three violation-of-expectation experiments, 9-month-olds (N = 120) expected an experimenter to divide two cookies equally between two animated puppets (1:1), and they detected a violation when she divided them unfairly instead (2:0). The same positive result was obtained whether the experimenter gave the cookies one by one to the puppets (Experiments 1-2) or first separated them onto placemats and then gave each puppet a placemat (Experiment 3). However, a negative result was obtained when four (as opposed to two) cookies were allocated: Infants looked about equally whether they saw a fair (2:2) or an unfair (3:1) distribution (Experiment 3). A final experiment revealed that 4-month-olds (N = 40) also expected an experimenter to distribute two cookies equally between two animated puppets (Experiment 4). Together, these and various control results support two broad conclusions. First, sensitivity to fairness emerges very early in life, consistent with claims that an abstract expectation of fairness is part of the basic structure of human moral cognition. Second, this expectation can at first be observed only under simple conditions, and speculations are offered as to why this might be the case.

| S-EPMC6389704 | biostudies-literature

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