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Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals

ABSTRACT: Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals.

PROVIDER: PRJEB86263 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR14720500_1.fastq.gz	Fastqsanger.gz
	ERR14720500_2.fastq.gz	Fastqsanger.gz
	ERR14720501_1.fastq.gz	Fastqsanger.gz
	ERR14720501_2.fastq.gz	Fastqsanger.gz
	ERR14720502_1.fastq.gz	Fastqsanger.gz

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Six months of gender affirming hormone treatment modifies the methylome in the transgender population

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Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals.

Project description:BackgroundLimited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. This study aimed to investigate the nuanced impact of sex steroids on gut microbiota taxonomy and function, addressing this gap. We prospectively analyzed gut metagenome changes associated with 12 weeks of GAHT in trans women and trans men, examining both taxonomic and functional shifts.MethodsThirty-six transgender individuals (17 trans women, 19 trans men) provided pre- and post-GAHT stool samples. Shotgun metagenomic sequencing was used to assess the changes in gut microbiota structure and potential function following GAHT.ResultsWhile alpha and beta diversity remained unchanged during transition, specific species, including Parabacteroides goldsteinii and Escherichia coli, exhibited significant abundance shifts aligned with affirmed gender. Overall functional metagenome analysis showed a statistically significant effect of gender and transition (R2 = 4.1%, P = 0.0115), emphasizing transitions aligned with affirmed gender, particularly in fatty acid-related metabolism.ConclusionsThis study provides compelling evidence of distinct taxonomic and functional profiles in the gut microbiota between trans men and women. GAHT induces androgenization in trans men and feminization in trans women, potentially impacting physiological and health-related outcomes.Trial registrationClinicaltrials.gov NCT02185274.

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Six months of gender affirming hormone treatment modifies the methylome in the transgender population

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CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment

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CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment

Project description:We measured whole-genome DNA methylation by the Illumina Infinium Human Methylation 850 array and reported its correlation with cortical thickness (CTh) in 22 transgender men (TM) experiencing GD versus 25 cisgender men (CM) and 28 cisgender women (CW). With respect to the methylation analysis, TM vs. CW showed significant differences in 35 CpGs, while 2,155 CpGs were found when TM vs. CM were compared. With respect to correlation analysis, TM showed differences in methylation of CBLL1 and DLG1 genes that correlated with global and left hemisphere CTh. Both genes were hypomethylated in TM compared to the cisgender groups. Early onset TM showed a positive correlation between CBLL1 and several cortical regions in the frontal (left caudal middle frontal), temporal (right inferior temporal, left fusiform) and parietal cortices (left supramarginal and right paracentral). This is the first study relating CBLL1 methylation with CTh in transgender persons and supports a neurodevelopmental hypothesis of gender identity

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