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Specialized post-arterial capillaries for adult bone remodeling [BoneEC]

ABSTRACT: Specialized post-arterial capillaries for adult bone remodeling [BoneEC]

PROVIDER: PRJNA1000447 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25473566_1.fastq.gz	Fastqsanger.gz
	SRR25473566_2.fastq.gz	Fastqsanger.gz
	SRR25473567_1.fastq.gz	Fastqsanger.gz
	SRR25473567_2.fastq.gz	Fastqsanger.gz
	SRR25473568_1.fastq.gz	Fastqsanger.gz

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Specialized post-arterial capillaries facilitate adult bone remodeling

Project description:Specialized post-arterial capillaries facilitate adult bone remodeling

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Specialized post-arterial capillaries for adult bone remodeling [Dach1OE]

Project description:Specialized post-arterial capillaries for adult bone remodeling [Dach1OE]

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Specialized post-arterial capillaries facilitate adult bone remodeling

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-08-22 | GSE239627 | GEO

Specialized post-arterial capillaries for adult bone remodeling [BoneEC]

Project description:A single cell transcriptomic profile of bone endothelial cells of the murine femur and tibia.

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Specialized post-arterial capillaries for adult bone remodeling [Dach1OE]

Project description:A single cell transcriptomic profile of bone stromal cells of the murine femur at postnatal day 30 (P30), Tamoxifen injected at Postnatal day 1 and 2.

2024-08-22 | GSE239625 | GEO

Genetic ablation of TonEBP/NFAT5 in smooth muscle cells inhibits arterial remodeling

Project description:Chronic biomechanical stress elicits remodeling of the arterial wall and causes detrimental arterial stenosis and stiffening. In this context, molecular determinants controlling proliferation and stress responses of vascular smooth muscle cells (VSMCs) have been insufficiently studied. We identified the transcription factor ‘nuclear factor of activated T-cells 5’ (NFAT5) as crucial regulatory element of mechanical stress responses of VSMCs. The relevance of this observation for biomechanically induced arterial remodeling was investigated in mice upon SMC-specific knockdown of NFAT5. While blood pressure levels, vascular architecture and flow-induced collateral growth were not affected in these mice, both hypertension-mediated arterial thickening and muscularization of pulmonary arteries during pulmonary artery hypertension (PAH) were impaired. In all models, a decrease in VSMC proliferation was observed indicating that NFAT5 controls activation of VSMCs in the remodeling arterial wall. Mechanistically, mechanoactivation of VSMCs promotes nuclear translocation NFTA5c upon its phosphorylation at Y143 and dephosphorylation at S1197. As evidenced by transcriptome studies, loss of NFAT5 in mechanoactivated VSMCs impairs expression of gene products controlling cell cycle and transcription/translation. These findings identify NFAT5 as molecular determinant of VSMC responses to biomechanical stress and arterial thickening.

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Bone Marrow-Derived NGFR-Positive Dendritic Cells Regulate Arterial Remodeling

Project description:Bone Marrow-Derived NGFR-Positive Dendritic Cells Regulate Arterial Remodeling

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Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling [lung]

Project description:Vascular remodeling is the process of structural alteration and cell rearrangement of blood vessels in response to injury and is the cause of many of the world's most afflicted cardiovascular conditions, including pulmonary arterial hypertension(PAH). Many studies have focused on the effects of vascular endothelial cells and smooth muscle cells(SMCs) during vascular remodeling, but pericytes, an indispensable cell population residing largely in capillaries, are ignored in this maladaptive process. Here we report that hypoxia-inducible factor 2α(HIF2α) expression is increased in human PAH patient lung tissues and HIF2α overexpressed pericytes result in greater contractility and an impaired endothelial-pericyte interaction. Using single-cell RNAseq and hypoxia-induced pulmonary hypertension(PH) models, we show HIF2α as a major molecular regulator for pericytes’ transformation into SMC-like cells. HIF2α overexpression in pericyte-selective mice exacerbate PH and right ventricular hypertrophy. Temporal cellular lineage tracing shows that HIF2α overexpressing reporter NG2+ cells (pericyte-selective) relocate from capillaries to arterioles and co-express SMA. This novel insight into the potential role of NG2+ pericytes in pulmonary vascular remodeling via HIF2α signaling suggests a potential drug target for PH.

2023-12-11 | GSE249461 | GEO

Bone Marrow-Derived NGFR-Positive Dendritic Cells Regulate Arterial Remodeling

Project description:It has been proposed that bone marrow contributes to the pathogenesis of arteriosclerosis. Nerve growth factor receptor (NGFR) is expressed in bone marrow stromal cells; it is also present in peripheral blood and ischemic coronary arteries. We hypothesized that bone marrow-derived NGFR-positive (NGFR+) cells regulate arterial remodeling. We found that human NGFR+ mononuclear cells (MNCs) in peripheral blood expressed markers for plasmacytoid dendritic cells (DCs) and were susceptible to apoptosis in response to proNGF secreted by activated arterial smooth muscle cells (SMCs). Bone marrow-specific depletion of NGFR+ cells increased neointimal formation following arterial ligation in mice. Bone marrow-derived NGFR+ cells accumulated in the neointima and underwent apoptosis. In contrast, in a bone marrow-specific NGFR-knockout model, SMCs occupied the neointima with augmented proliferation. NGFR+ cells in the neointima promoted mannose receptor C-type 1-positive antiinflammatory macrophage accumulation and secreted antiinflammatory IL-10, thereby inhibiting SMC proliferation in the neointima. In patients with acute coronary syndrome (ACS), NGFR+ peripheral MNCs increased after ACS onset. Multiple linear regression analysis showed that an insufficient increase in NGFR+ peripheral MNCs in ACS was an adjusted independent risk factor for 9-month intimal progression of a nontargeted lesion. Taken together, these observations imply that bone marrow-derived NGFR+ DCs are suppressors of arteriosclerosis.

2024-12-18 | GSE238076 | GEO

Proteome analysis of adult mouse brain capillaries

Project description:Isolated brain capillaries are essential for analyzing the changes of protein expressions at the blood-brain barrier (BBB) under pathological conditions. The standard brain capillary isolation methods require the use of at least 5 mouse brains in order to obtain a sufficient amount and purity of brain capillaries. The purpose of this study was to establish a brain capillary isolation method from a single mouse brain for protein expression analysis.

2023-07-12 | PXD041770 | JPOST Repository

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