Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Patient-derived models of prostate cancer

ABSTRACT: Patient-derived models of prostate cancer

PROVIDER: PRJNA1000653 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Patient-derived models of prostate cancer

Project description:Patient-derived models of prostate cancer

| PRJNA1000652 | ENA

Patient-Derived Models of Prostate Cancer for Personalized Medicine

Project description:Patient-Derived Models of Prostate Cancer for Personalized Medicine

| PRJNA1018661 | ENA

Genome scale analysis of DNA methylation patterns in prostate cancer patient derived xenograft models [EPIC Set 1]

Project description:DNA methylation alterations are a universal feature of cancer. In prostate cancer, site specific DNA methylation changes have been suggested as driver in disease initial and progression. Here we provide a comprehensive assessment of DNA methylation changes in prostate cancer patient derived xenograft (PDX) models. We delineate patterns of both site specific and global methylation changes and nominate novel candidates for biomarker development. Genome wide DNA methylation profiling of prostate cancer patient derived xenograft and cell line models using Infinium EPIC arrays

2023-12-31 | GSE227814 | GEO

Genome scale analysis of DNA methylation patterns in prostate cancer patient derived xenograft models [EPIC Set 2]

2023-12-31 | GSE227695 | GEO

Proteomics of prostate cancer patient derived xenografts

Project description:A set of 17 prostate cancer patient-derived xenografts (PDX, Lin et al 2014, Cancer research) was analyzed by mass spectrometry-based proteomics to characterize the effects of castration in vivo, and the proteome differences between NEPC and prostate adenocarcinomas.

2019-09-11 | PXD009636 | Pride

Patient Derived Xenograft for Delivery of Precision Medicine in Castrate Resistant Prostate Cancer

Project description:Developing animal models representating the cancer biology of advanced prostate cancer patients is challenging but essential for delivering individualized medical therapies. In an effort to develop patient derived xenograft (PDX) models, we took the metastatic site tissue from the rib lesion twice (ie, before and after enzalutamide treatment) over a twelve week period and implanted subcutaneously and under the renal capsule in immuno-deficient mice. To characterize and compare the genome and transcriptome landscapes of patient tumor tissues and the corresponding PDX models, we performed whole exome and transcriptome sequencing for metastatic tumor tissue as well as its derived PDXs. We demonstrated the feasibility of developping PDX models from patient who developed castrate-resistant prostate cancer. Our data suggested PDX models preserve the patient’s genomic and transcriptomic alterations in high fidelity, as illustrated by somatic mutation, copy number variation, gene fusion and gene expression. RNA sequencing of prostate cancer tumor tissue and derived xenograft using Illumina HiSeq 2000.

2015-06-30 | E-GEOD-70380 | biostudies-arrayexpress

DNA methylation alterations in prostate cancer patient derived xenograft models revealed by whole genome bisulfite sequencing

2023-12-31 | GSE227086 | GEO

chromatin Remodeling in Patient-Derived Colorectal Cancer Models

Project description:chromatin Remodeling in Patient-Derived Colorectal Cancer Models

| PRJNA764740 | ENA

Genome scale analysis of DNA methylation patterns in prostate cancer patient derived xenograft models

Project description:Genome scale analysis of DNA methylation patterns in prostate cancer patient derived xenograft models

| PRJNA947185 | ENA

Neuroendocrine prostate cancer models

Project description:Neuroendocrine prostate cancer models

| PRJNA449097 | ENA