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A role for BCL6 in maintaining CX3CR1+ CD4+ T cells during helminth infection

ABSTRACT: A role for BCL6 in maintaining CX3CR1+ CD4+ T cells during helminth infection

PROVIDER: PRJNA1001051 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25485630.fastq.gz	Fastqsanger.gz
	SRR25485631.fastq.gz	Fastqsanger.gz
	SRR25485632.fastq.gz	Fastqsanger.gz
	SRR25485633.fastq.gz	Fastqsanger.gz
	SRR25485634.fastq.gz	Fastqsanger.gz

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Similar Datasets

A role for BCL6 in maintaining CX3CR1+ CD4+ T cells during helminth infection

Project description:Distinct subsets of T lymphocytes express CX3CR1 under inflammatory conditions, but little is known about CX3CR1+ CD4+ T cells during Type 2 inflammation in helminth infections. Here, we used a fate-mapping mouse model to characterize CX3CR1+ CD4+ T cells during both acute Nippostrongylus brasiliensis and chronic Schistosoma mansoni helminth infections, revealing CX3CR1+ CD4+ T cells to be an activated tissue homing subset with varying capacity for cytokine production. Tracking these cells over time revealed that maintenance of CX3CR1 itself along with a TH2 phenotype conferred a survival advantage in the inflamed tissue. Single-cell RNA-sequencing analysis of fate-mapped CX3CR1+ CD4+ T cells from both the peripheral tissue and the spleen revealed a considerable level of diversity and identified a distinct population of BCL6+ TCF-1+ PD1+ CD4+ T cells in the spleen during helminth infections. Conditional deletion of BCL6 in CX3CR1+ cells result in fewer CX3CR1+ CD4+ during infection, indicating a role in sustaining CD4+ T cell responses to helminth infections. Overall, our studies revealed the behavior and heterogeneity of CX3CR1+ CD4+ T cells during Type 2 inflammation in helminth infections and identified BCL6 to be important in their maintenance

2023-08-12 | GSE239846 | GEO

Bcl6 controlled gene expression in naïve CD4 T cells (Tf0)

Project description:Gene expression data from wild-type and Bcl6-/- naive CD4 T cells In order to find genes regulated by Bcl6 in follicular helper T cells Naïve CD4 T cells were sorted from wild-type (WT) and T cell-specific conditional Bcl6-/- (KO) mice-- 8 samples, 4 WT and 4 KO

2015-04-08 | E-GEOD-67622 | biostudies-arrayexpress

Bcl6 controlled gene expression in naïve CD4 T cells (Tfh)

2015-04-08 | E-GEOD-67623 | biostudies-arrayexpress

Bcl6 controlled gene expression in naïve CD4 T cells (Tfh)

Project description:Gene expression data from wild-type and Bcl6-/- naive CD4 T cells In order to find genes regulated by Bcl6 in follicular helper T cells

2015-04-08 | GSE67623 | GEO

Bcl6 controlled gene expression in naïve CD4 T cells (Tf0)

Project description:Gene expression data from wild-type and Bcl6-/- naive CD4 T cells In order to find genes regulated by Bcl6 in follicular helper T cells

2015-04-08 | GSE67622 | GEO

Population gene expression of anti-viral CD4 T cells in Bcl6 and Blimp1 deficient conditions

Project description:Population gene expression of effector CD4+ T cells WT, Bcl6-deficient , Blimp1-deficient or Bcl6 Blimp1-deficient was determined by RNAseq after LCMV Armstrong infection

2021-11-05 | GSE149597 | GEO

Single-cell gene expression of anti-viral CD4 T cells in Bcl6 and Blimp1 deficient conditions

Project description:Single-cell gene expression of effector CD4+ T cells WT, Bcl6-deficient , Blimp1-deficient or Bcl6 Blimp1-deficient was determined by scRNAseq after LCMV Armstrong infection

2021-11-05 | GSE149912 | GEO

RNA sequencing comparison of CXCR3+ and CX3CR1+ CD4+ epitope specific T cells from Se-infected mice.

Project description:Interferon-γ (IFN-γ)-producing CD4+ T helper-1 (Th1) cells are critical for protection from microbes that infect the phagosomes of myeloid cells. We assessed Th1 cell generation in vivo by studying antigen-specific CD4+ T cells during infection with the phagosomal pathogen Salmonella enterica. We found that this infection induced two varieties of Th1 cells, one expressing CXCR3 and one expressing CX3CR1. We performed RNA sequencing on these two types of Th1 cells that were specific for the LpdAp:I-Ab epitope from B6 x 129 F1 mice 30 days after Salmonella enterica infection to gain information about the differences between these types of Th1 cells and how those differences might relate to protective immunity. We report results for CXCR3+ CX3CR1- and CXCR3- CX3CR1+ LpdAp:I-Ab-tetramer binding cells.

2021-03-18 | GSE168300 | GEO

Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+4

Project description:We isolated CD4+ T cells from mice vaccinated against, and challenged with, Brucella to investigate the function of CD4+ T cell intrinsic BCL6 signaling

2024-01-24 | GSE243861 | GEO

Transcriptional profiling of CD4 T cells from control mice and from mice lacking BCL6 expression in CD4+ T cells 4+2

Project description:We isolated CD4+ T cells from mice vaccinated against, and challenged with, Brucella to investigate the function of CD4+ T cell intrinsic BCL6 signaling

2024-01-24 | GSE243859 | GEO

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