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Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (blood)

ABSTRACT: Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (blood)

PROVIDER: PRJNA1001501 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25498700_1.fastq.gz	Fastqsanger.gz
	SRR25498700_2.fastq.gz	Fastqsanger.gz
	SRR25498701_1.fastq.gz	Fastqsanger.gz
	SRR25498701_2.fastq.gz	Fastqsanger.gz
	SRR25498702_1.fastq.gz	Fastqsanger.gz

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Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (TCR)

Project description:Immune escape is a prerequisite of tumor growth. We previously described a decline in intratumor activated GZMB+CD8+ T cells and T cell receptor (TCR) clonotype diversity in invasive compared to in situ (DCIS) breast carcinomas implying a role for decreasing TCR diversity in tumor progression. Here, we evaluated peripheral blood TCR clonotype diversity in breast cancer patients diagnosed with DCIS or de novo stage IV disease at different ages. We found that peripheral TCR diversity is associated with clinicopathologic, and peripheral immune status and it correlates with the frequency of CD8+ T cells in DCIS of young patients. These results provide new insights to the role of host immunity and breast cancer development in different aged women.

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Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (blood)

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Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (TCR)

Project description:Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression (TCR)

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Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression

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Peripheral blood TCR clonotype diversity as an age-associated marker of breast cancer progression

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:The ability to monitor anti-tumor CD8+ T cell responses in the blood has tremendous therapeutic potential. However, tracking tumor antigen-specific CD8+ T cells in the blood is challenging due to their small number and limited reagents to track these cells. We asked whether paired single-cell RNA and T cell receptor (TCR) sequencing could be used to detect and characterize “tumor matching” (TM) CD8+ T cells in the blood of mice with MC38 tumors using the TCR as a molecular barcode. By leveraging the transcriptome, we characterized these cells, and identified candidate cell surface markers for to enrich this population. These data show that the TCR can be used to identify tumor-relevant cells for characterization, reveal unique transcriptional properties of TM cells, and develop marker panels for tracking and analysis of these cells.

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